Results 81 to 90 of about 2,195 (197)

Engineering Gypsophila elegans hairy root cultures to produce endosomal escape‐enhancing saponins

Plant Biotechnology Journal, Volume 23, Issue 8, Page 3068-3082, August 2025.
Summary The limited cytosolic delivery of DNA and protein‐based therapeutics due to endosomal entrapment reduces drug efficacy, increasing treatment costs and possible side effects in human and veterinary medicine as a consequence of higher administered dosages.
Elia Lacchini, Tongtong Qu, Tessa Moses, Alexander N. Volkov, Alain Goossens   +4 more
wiley   +1 more source

Anti-Herpes Zoster Vaccination of Fragile Patients in Hospital Setting: A Nudge Intervention in Italy

Vaccines
Background: A nudge intervention against Herpes Zoster, created and implemented in Italy, is presented in order to administer the Shingrix vaccine on a sample of frail patients, as required by the National Prevention Plan.
Francesco De Caro, Francesca Malatesta, Nadia Pecoraro, Mario Capunzo, Luna Carpinelli, Simona Caruccio, Giuseppina Cersosimo, Maria Costantino, Claudio Giordano, Walter Longanella, Vincenzo Patella, Arcangelo Saggese Tozzi, Giulia Savarese, Pio Sinopoli, Emilia Anna Vozzella, Giuseppina Moccia   +15 more
doaj   +1 more source

Immune Aging, Immunosenescence, and Inflammaging: Implications for Vaccine Response in Older Adults

Health Science Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background and Aims Population aging is a significant demographic change while vaccines are mostly made for children and young adults and their effectiveness might be low in the older population. Age‐associated decline in the immune function (immunosenescence) is a process that may lead to poor vaccine response in the older population.
Shahab Falahi, Amir Abdoli, Azra Kenarkoohi   +2 more
wiley   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, Volume 21, Issue 29, July 24, 2025.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Lipo-pam™ adjuvanted herpes zoster vaccine induces potent gE-specific cellular and humoral immune responses

npj Vaccines
Herpes zoster (HZ), also known as shingles, is caused by the reactivation of latent varicella-zoster virus (VZV). Decreased VZV-specific T-cell immune responses significantly contribute to the development of HZ.
Soo-Kyung Jeong, Su-Jin Ham, Seung-Hee Baek, Eun-Jung Jung, Hyun-Jin Jo, Hye-Ran Cha, Jae-Myun Lee, Byung Cheol Ahn, Jung Sun Yum, Eunyoung Chun   +9 more
doaj   +1 more source

Association Between Child Varicella Vaccination and Zoster in Household Adults: A Retrospective Japanese Cohort Study

Acta Paediatrica, Volume 114, Issue 6, Page 1392-1398, June 2025.
ABSTRACT Aim Some countries are hesitant to implement routine varicella vaccination for children because of concerns over the exogenous boosting hypothesis, which suggests that vaccinating children may increase herpes zoster cases in adults. However, substantial evidence supporting this hypothesis is lacking. This study assessed the association between
So Sato, Sachiko Ono, Yusuke Sasabuchi, Nobuaki Michihata, Kohei Uemura, Hideo Yasunaga   +5 more
wiley   +1 more source

Herpes zoster ophthalmicus despite shingrix immunization

Advances in Ophthalmology & Visual System
Background: Herpes zoster ophthalmicus (HZO) is a reactivation of the varicella-zoster virus causing serious ocular and systemic complications, particularly in individuals with declining immunity. Case report: A 74-year-old male with a history of various chronic conditions was referred to an eye clinic due to herpes zoster affecting his right forehead
Len V Koh, Chad E Gosnell, Allison C Makadia, Virginia O Bice, Kyle P Criswell   +4 more
openaire   +1 more source

Exploring the Role of Pattern Recognition Receptors as Immunostimulatory Molecules

Immunity, Inflammation and Disease, Volume 13, Issue 5, May 2025.
This mini‐review summarizes different classes of pattern recognition receptors (PRRs) and the role of their agonizts that have been identified and also outlines the role of PRR ligands as immunostimulatory molecules. Overall, the mini‐review has elaborated on the role of PRRs in the development of therapeutic vaccine adjuvants.
Meenal Sharma, Priyanka Wagh, Tanvi Shinde, Diptee Trimbake, Anuradha S. Tripathy   +4 more
wiley   +1 more source

The Shingrix Vaccine: Information for Patients About Current Recommendations & the National Shortage [PDF]

, 2018
In the US, herpes zoster and related complications have been estimated to result in 1.3 billion dollars of medical costs alone annually. In order to combat this significant public health burden, efforts have been made to vaccinate susceptible populations
Shah, Purvi
core   +1 more source

Vaccine Adjuvants in the Immunocompromised Host: Science, Safety, and Efficacy

Transplant Infectious Disease, Volume 27, Issue 3, May/June 2025.
ABSTRACT Vaccine adjuvants are essential for enhancing immune responses to vaccines, particularly in immunocompromised populations who typically demonstrate suboptimal responses to standard vaccination. This narrative review evaluates the safety and efficacy of approved and candidate adjuvants in immunocompromised hosts, with emphasis on solid organ ...
Haya Hayek, Lana Hasan, Justin Z. Amarin, Yasmeen Z. Qwaider, Olla Hamdan, Wanderson Rezende, Kevin C. Dee, James D. Chappell, Natasha B. Halasa   +8 more
wiley   +1 more source