Results 21 to 30 of about 1,249,958 (308)

Hemorrhagic shock

open access: yesActa chirurgica Iugoslavica, 2007
Hemorrhagic shock is a condition produced by rapid and significant loss of blood which lead to hemodynamic instability, decreases in oxygen delivery, decreased tissue perfusion, cellular hypoxia, organ damage and can be rapidly fatal. Despite improved understanding of the pathophysiology and significant advances in technology, it remains a serious ...
V, Bumbasirević   +9 more
openaire   +3 more sources

Role of activated dynamin-related protein 1-mediated glutathione metabolism in regulation of mitochondrial dysfunction after hemorrhagic shock

open access: yesDi-san junyi daxue xuebao, 2020
Objective To explore the relationship between activated dynamin-related protein 1 (Drp1)-mediated mitochondrial function and energy metabolism after hemorrhagic shock and clarify its potential mechanisms.
DUAN Chenyang   +4 more
doaj   +1 more source

A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3‐WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force

open access: yesEpilepsia Open, EarlyView., 2022
Abstract Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic–ischemic injury, infection, status epilepticus, or brain trauma. These conditions are frequently modeled in experimental rodents to delineate mechanisms of epileptogenesis and investigate novel therapeutic strategies.
Anna‐Maria Katsarou   +7 more
wiley   +1 more source

Oxygen Regime and Exchange of Ammonia in the Sensomotor Cortex of Cats During Blood Loss and Hyperbaric Oxygenation

open access: yesОбщая реаниматология, 2020
Purpose. To study the effect of hyperbaric oxygenation (HBO) on the oxygen regime and ammonia metabolism in the neurons of cat cortex in hemorrhagic shock.Material and methods. Experiments were performed on 164 cats (males).
V. N. Yakovlev, P. N. Savilov
doaj   +1 more source

Outcomes of traumatic hemorrhagic shock and the epidemiology of preventable death from injury

open access: yesTransfusion, 2019
The majority of potentially preventable deaths after trauma are related to hemorrhage and occur early after injury, with the largest number of deaths occurring before hospital arrival.
B. Eastridge, J. Holcomb, S. Shackelford
semanticscholar   +1 more source

Protective effect of pericytes against vascular leakage in rats with hemorrhagic shock

open access: yesDi-san junyi daxue xuebao, 2020
Objective To investigate the protective effect of pericytes (PCs) against vascular leakage in rats with hemorrhagic shock. Methods Sixty-four 12- to 24-week-old SD rats weighing 200~220 g were randomized equally into sham-operated group, hemorrhagic ...
HE Shuangshuang   +5 more
doaj   +1 more source

Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation. [PDF]

open access: yesPLoS ONE, 2011
The early use of fresh frozen plasma as a resuscitative agent after hemorrhagic shock has been associated with improved survival, but the mechanism of protection is unknown.
Ricky J Haywood-Watson   +9 more
doaj   +1 more source

Platelet-derived- Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock

open access: yesScientific Reports, 2019
Every year more than 500,000 deaths are attributed to trauma worldwide and severe hemorrhage is present in most of them. Transfused platelets have been shown to improve survival in trauma patients, although its mechanism is only partially known. Platelet
Ernesto Lopez   +10 more
semanticscholar   +1 more source

Recruitment of neutrophils across the blood-brain barrier: the role of posttraumatic hepatic ischemia [PDF]

open access: yesActa Cirúrgica Brasileira, 2003
PURPOSE: To study the effects of total hepatic ischemia, and reperfusion on the accumulation of neutrophils in the brain of rats submitted to normovolemic conditions as well as to controlled hemorrhagic shock state.
Mario Mantovani   +4 more
doaj   +1 more source

Protective Effects of the Complement Inhibitor Compstatin CP40 in Hemorrhagic Shock

open access: yesShock, 2018
Trauma-induced hemorrhagic shock (HS) plays a decisive role in the development of immune, coagulation, and organ dysfunction often resulting in a poor clinical outcome.
M. van Griensven   +20 more
semanticscholar   +1 more source

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