Results 141 to 150 of about 610,317 (302)

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

An ovine septic shock model of live bacterial infusion

Background: Escherichia coli is the most common cause of human bloodstream infections and bacterial sepsis/septic shock. However, translation of preclinical septic shock resuscitative therapies remains limited mainly due to low-fidelity of available ...
Obonyo, NG, Palmieri, C, Wilson, ES, Gandini, L, Bouquet, M, Farah, SM, Sato, K, Raman, S, Liu, K, Suen, JY, Passmore, MR, Hyslop, K, White, N, Phan, MD, et al., Peters, KM   +15 more
core   +1 more source

Septic Shock After Kidney Transplant: A Rare Bloodstream Ralstonia mannitolilytica Infection

, 2022
Xiangyong Tian,1,* Nan Jing,2,* Wenjing Duan,3 Xiaoqiang Wu,1 Chan Zhang,1 Shanmei Wang,2 Tianzhong Yan1 1Department of Urology, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital ...
Tian X, Wang S, Jing N, Yan T, Zhang C, Duan W, Wu X   +6 more
core  

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Association of metformin administration after septic shock with short-term and long-term survival in septic shock patients with diabetes

Annals of Intensive Care
Background In addition to glycemic control, the anti-inflammatory effects and protective effect of metformin on sepsis have been reported in animal studies, which may be beneficial for patients with septic shock.
Bo-Yeong Jin, Sukyo Lee, Woosik Kim, Jong-Hak Park, Hanjin Cho, Sungwoo Moon, Sejoong Ahn   +6 more
doaj   +1 more source

Septic shock [PDF]

, 2018
Septic shock continues to be a leading cause of surgical mortality. Between 1965 and 1971, 105 cases of septic shock were observed at a large teaching hospital in Glasgow.
Gray, N
core  

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

Septic Shock

Annals of Surgery, 1956
W A, ALTEMEIER, W, COLE
openaire   +3 more sources

Corticosteroids in patients with septic shock

, 1987
C
Vincent, JLeditor, Thijs, LGeditor, Vogelaers, DirkGE35UZGent8010004613140000-0002-7707-285XF403D642-F0ED-11E1-A9DE-61C894A0A6B4, Colardyn, FrancisUGent801000226692821000226660F365F0F8-F0ED-11E1-A9DE-61C894A0A6B4   +3 more
core  

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source