Results 181 to 190 of about 895,705 (294)

Cross-Market Risk Spillovers in China: A Multidimensional and Nonlinear Transmission Perspective. [PDF]

Entropy (Basel)
Zou Y, Chen Q, Han J, Zhao L.
europepmc   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Pathogen-associated heterogeneity in pulmonary sepsis: from inflammatory phenotypes and transcriptomic endotypes to precision medicine. [PDF]

Front Immunol
Wang C, Xi C, Zhang Y, Ma R, Shi M, Gao Y, Liu L, Ning C, Chen A.   +8 more
europepmc   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Learning is a fundamental source of individuality. [PDF]

Elife
Manna R, Brea J, Vasconcelos Braga GN, Modirshanechi A, Tomić I, Jakšić AM.   +5 more
europepmc   +1 more source

A Worm‐Inspired Origami Robot with Multimodal Locomotion for Adaptive Mobility in Complex Pipeline Environments

Advanced Science, EarlyView.
An origami worm‐inspired robot achieves multimodal locomotion in confined pipelines through mechatronic integration that embeds actuation, control, and communication within each origami module. Large, reversible configuration and dimensional changes enable 25 gaits synthesized by a unified framework across peristaltic, inchworm, and wheel‐rolling modes
Qiwei Zhang, Kangning Tan, Zihan He, Hongsen Pang, Yanjie Wang, Hongbin Fang, Jian Xu   +6 more
wiley   +1 more source

Generative AI for efficient statistical computation of fluids. [PDF]

Nat Commun
Raonić B, Molinaro R, Lanthaler S, Rohner T, Armegioiu V, Simonis S, Grund D, Ramic Y, Wan ZY, Sha F, Mishra S, Zepeda-Núñez L.   +11 more
europepmc   +1 more source

Rod Origami (RodOri) Spring Metamaterials for Tunable Vibration Control via Tailored Structural Instabilities

Advanced Science, EarlyView.
Rod Origami (RodOri) springs harness snap‐through instabilities of pre‐stressed curved rods with geometrically programmable buckling behavior. Integrating RodOri springs with distinct geometries yields multistable metamaterials that undergo stepwise reconfiguration via sequential snapping, achieving wide‐range tunability of stiffness and resonance ...
Jeseung Lee, Sophie Leanza, Ruike Renee Zhao   +2 more
wiley   +1 more source

Physics-informed neural network with weighted loss and hard constraints for hyperbolic conservation laws. [PDF]

Sci Rep
Ghoreishi MS, Naderan H.
europepmc   +1 more source

Single‐Step Electrochemical Aptasensor for Melatonin Detection in Unprocessed Plasma

Advanced Science, EarlyView.
Melatonin is a well‐known biomarker with significant potential for clinical use in diagnosing circadian rhythm sleep disorders (CRSDs) and monitoring patients with documented circadian clock disruption. An electrochemical aptamer‐based biosensor (E‐aptasensor), employing an optimized population of melatonin aptamers, has been proposed as a solution for
Hamed Shieh, Arash Khorrami Jahromi, Fernando Gonzales‐Aste, Sajad Shiekh, Roozbeh Siavash Moakhar, Sahar Sadat Mahshid, Sara Mahshid   +6 more
wiley   +1 more source