Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
On the global existence and stability of 3-D viscous cylindrical circulatory flows [PDF]
arXiv, 2017 In this paper, we are concerned with the global existence and stability of a 3-D perturbed viscous circulatory flow around an infinite long cylinder. This flow is described by 3-D compressible Navier-Stokes equations. By introducing some suitably weighted energy spaces and establishing a priori estimates, we show that the 3-D cylindrical symmetric ...
arxiv
A numerical method for junctions in networks of shallow-water channels [PDF]
, 2017 There is growing interest in developing mathematical models and appropriate numerical methods for problems involving networks formed by, essentially, one-dimensional (1D) domains joined by junctions.
Bellamoli, Francesca +2 more
core +2 more sources
PATHOPHYSIOLOGICAL ROLES OF PEROXYNITRITE IN CIRCULATORY SHOCK [PDF]
Shock, 2010 Peroxynitrite is a reactive oxidant produced from nitric oxide and superoxide, which reacts with proteins, lipids, and DNA, and promotes cytotoxic and proinflammatory responses. Here, we overview the role of peroxynitrite in various forms of circulatory shock.
Csaba Szabó, Katalin Módis
openaire +3 more sources
Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury
Advanced Science, EarlyView.Based on the biodegradability and the immunological reactiveness, IMNs can be broadly classified into four categories. The first category includes types of biologically derived materials that cause immunomodulatory action and biodegradability like nanoparticles of cell membranes, extracellular vesicles, and exosomes.
Chenli Zhang +5 more
wiley +1 more source
Mortality for circulatory and respiratory causes associated with influenza circulation in Russia during the 2013/14 through the 2018/19 seasons [PDF]
arXiv, 2019 Background: Information on influenza-associated mortality in Russia is limited. Methods: Using previously developed methodology (Goldstein et al., Epidemiology 2012), we regressed the monthly rates of mortality for respiratory causes, as well as circulatory causes linearly against the monthly proxies for the incidence of influenza A/H3N2, A/H1N1 and ...
arxiv
Relation between respiratory variations in pulse oximetry plethysmographic waveform amplitude and arterial pulse pressure in ventilated patients. [PDF]
, 2005 IntroductionRespiratory variation in arterial pulse pressure is a reliable predictor of fluid responsiveness in mechanically ventilated patients with circulatory failure.
Besnard, Cyril +4 more
core +2 more sources
Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices
Advanced Science, EarlyView.In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley +1 more source
Influenza-associated mortality for circulatory and respiratory causes during the 2013-2014 through the 2018-2019 influenza seasons in Russia [PDF]
arXiv, 2019 Background: Information on influenza-associated mortality in Russia is limited. Methods: Using previously developed methodology (Goldstein et al., Epidemiology 2012), we regressed the monthly rates of mortality for respiratory causes, as well as circulatory causes linearly against the monthly proxies for the incidence of influenza A/H3N2, A/H1N1 and ...
arxiv
Does Bohm's Quantum Force Have a Classical Origin? [PDF]
, 2014 In the de Broglie - Bohm formulation of quantum mechanics, the electron is stationary in the ground state of the hydrogen atom, because the quantum force exactly cancels the Coulomb attraction of the electron to the proton. In this paper it is shown that classical electrodynamics similarly predicts the Coulomb force can be effectively canceled by part ...
arxiv +1 more source