Results 131 to 140 of about 990,795 (392)

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Exosomes and their roles in the chemoresistance of pancreatic cancer

Cancer Medicine, Volume 11, Issue 24, Page 4979-4988, December 2022., 2022
Despite the development of multiple promising chemotherapeutic agents as recommended first‐line treatment for PC, the therapeutic efficacy is largely limited by unwanted drug resistance.Exploring the relation between exosomes and chemoresistance may be conducive to understanding molecular mechanisms and taking effective measures to reduce the ...
Yubin Pan, Honglin Tang, Qijun Li, Guangpeng Chen, Da Li   +4 more
wiley   +1 more source

Circulatory Failure among Hospitalizations for Heatstroke in the United States

Medicines, 2020
Background: This study aimed to assess the risk factors and the association of circulatory failure with treatments, complications, outcomes, and resource utilization in hospitalized patients for heatstroke in the United States.
Tarun Bathini, Charat Thongprayoon, Tananchai Petnak, Api Chewcharat, Wisit Cheungpasitporn, Boonphiphop Boonpheng, Ronpichai Chokesuwattanaskul, Narut Prasitlumkum, Saraschandra Vallabhajosyula, Wisit Kaewput   +9 more
doaj   +1 more source

Observations on cardiogenic shock [PDF]

, 1965
The circulatory, arterial blood gas tension and metabolic changes following acute myocardial infarction have been studied serially in patients with and without cardiogenic shock.
Mackenzie, Gordon James
core  

Circulatory shock syndrome [PDF]

, 1998
Circulatory shock is marked by critical reductions on tecidual perfusion, causing severe systemic alterations, impairing cellular and organic function, with a high mortality rate as result.
Basile-Filho, Anibal, Marson, Flávio, Pazin Filho, Antonio, Pereira Junior, Gerson A.   +3 more
core   +2 more sources

Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives

Advanced Science, EarlyView.
Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.
Sung‐Hyun Kim, Sumin Yang, Jeehye Jung, Jeonghyeon Choi, Mingon Kang, Jae‐Yeol Joo   +5 more
wiley   +1 more source

Evaluation of factors associated with selection for coronary angiography and in‐hospital mortality among patients presenting with out‐of‐hospital cardiac arrest without ST‐segment elevation

Catheterization and Cardiovascular Interventions, Volume 100, Issue 7, Page 1159-1170, December 1, 2022., 2022
Abstract Background Clinical factors favouring coronary angiography (CA) selection and variables associated with in‐hospital mortality among patients presenting with out‐of‐hospital cardiac arrest (OHCA) without ST‐segment elevation (STE) remain unclear.
Wayne C. Zheng, Samer Noaman, Riley J. Batchelor, Laura Hanson, Jason E. Bloom, Omar Al‐Mukhtar, Kawa Haji, Nicholas D'Elia, Felicia C. S. Ho, David Kaye, James Shaw, Yang Yang, Craig French, Dion Stub, Nicholas Cox, William Chan   +15 more
wiley   +1 more source

Influenza-associated mortality for different causes of death during the 2010-2011 through the 2014-2015 influenza seasons in Russia [PDF]

arXiv, 2019
Background: There is limited information on the volume of influenza-associated mortality in Russia. Methods: Using previously developed methodology (Goldstein et al., Epidemiology 2012), we regressed the monthly rates of mortality for respiratory causes, circulatory causes, and for certain infectious and parasitic diseases (available from the Russian
arxiv  

Complications of Temporary Percutaneous Mechanical Circulatory Support for Cardiogenic Shock: An Appraisal of Contemporary Literature

Cardiology and Therapy, 2019
Cardiogenic shock (CS) is associated with hemodynamic compromise and end-organ hypoperfusion due to a primary cardiac etiology. In addition to vasoactive medications, percutaneous mechanical circulatory support (MCS) devices offer the ability to support ...
Anna V. Subramaniam, G. Barsness, S. Vallabhajosyula, S. Vallabhajosyula   +3 more
semanticscholar   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source