Results 31 to 40 of about 107,029 (283)

Pyroshock Response Prediction of Spacecraft Structure in Wide Frequency Domain Based on Acceleration FRF

Aerospace, 2022
The initiating explosive shock environment of an aerospace mission has the characteristics of instantaneity, high amplitude and a wide frequency domain.
Xiong Wang, Wei Liu, Jifeng Ding, Yi Sun, Yongbing Dang   +4 more
doaj   +1 more source

Numerical Study on Dynamic Characteristics of Vehicle Entering Water at High Speed

Journal of Marine Science and Engineering, 2022
Aiming at a design for buffering and load reduction configuration for a large-scale (diameter greater than 500 mm) vehicle entering water at high speed (greater than 100 m/s), a numerical model for a vehicle entering water at high speed was employed ...
Zhenpeng Liu, Yao Shi, Guang Pan, Hairui Zhao   +3 more
doaj   +1 more source

Ultrafast Fiber Bragg Grating Interrogation for Sensing in Detonation and Shock Wave Experiments

Sensors, 2017
Chirped fiber Bragg grating (CFBG) sensors coupled to high speed interrogation systems are described as robust diagnostic approaches to monitoring shock wave and detonation front propagation tracking events for use in high energy density shock physics ...
George Rodriguez, Steve M. Gilbertson
doaj   +1 more source

Research on Load Spectrum Reconstruction Method of Exhaust System Mounting Bracket of a Hybrid Tractor Based on MOPSO-Wavelet Decomposition Technique

Agriculture, 2023
To overcome the limitations of the hybrid tractor bumping tests, which include extended cycle times, high costs, and impracticality for single-part reliability verification, this study focuses on the exhaust system mounting bracket of a hybrid tractor. A
Liming Sun, Mengnan Liu, Zhipeng Wang, Chuqiao Wang, Fuqiang Luo   +4 more
doaj   +1 more source

Shock Vibration Control of SDOF Systems with Tubular Linear Eddy Current Dampers

Applied Sciences, 2023
The nonlinear dynamic characteristic of a tubular linear eddy current damper (TLECD) and the transient responses to shock excitations of a single-degree-of-freedom (SDOF) system with the TLECD are studied. First, the nonlinear force-velocity relationship
Yida Pu, Zhiwen Huang, Hongyi Zhang, Xugang Hua, Yousheng Xu   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Research on the Shock Environment Characteristics of a Marine Diesel Engine Based on a Large Floating Shock Platform

Journal of Marine Science and Engineering, 2023
To conduct a precise shock assessment of marine diesel engines, a 200 t floating shock platform was utilized to simulate realistic testing conditions. The testing generated the acceleration time curve and the shock response spectrum for the diesel engine.
Yu Zhang, Jun Li, Chunhui Zhang, Wei Chen, Zhipeng Du, Xiaobin Li   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source