Results 81 to 90 of about 109,128 (264)

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

STEAM INDUCED SHOCKWAVE INTERACTION WITH A SUBMERGED PLATE CONFIGURED AT A RANGE OF INCLINATIONS FROM VERTICAL

Yanbu Journal of Engineering and Science
Interaction of shock wave and the shear induced vortex across the steam-water layer has been vital in several transportation and chemical industrial processes.
Saeed Almalowi, Afrasyab Khan
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Laser-plasma induced shock waves in micro shock tubes

New Journal of Physics, 2017
Shock wave generation with help of lasers or shock tubes, for example, is a common subject at macroscopic scale. On the other hand, the current tendency towards smaller scales becomes more and more important.
Ulrich Teubner, Yun Kai, Theodor Schlegel, David E Zeitoun, Walter Garen   +4 more
doaj   +1 more source

Single-Pulse Shock Tube Pyrolysis Study of RP-3 Jet Fuel and Kinetic Modeling. [PDF]

ACS Omega, 2021
Zeng P, Wang BY, He R, Liang J, Yang ZY, Xia ZX, Wang QD.   +6 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

CFD Modelling of Flow Characteristics in Micro Shock Tubes

Journal of Applied Fluid Mechanics, 2017
The use of micro shock tubes has become common in many instruments requiring a high velocity and temperature flow field, for example in micro-propulsion systems and drug delivery devices for medical systems.
A. Mukhambetiyar, M. Jaeger, D. Adair
doaj  

Study on the Variation in Shock Characteristics in a TNT-Based Shock Tube Under Different Experimental Conditions

Applied Sciences
In open-air explosion experiments, the measured blast pressure characteristics often show high Coefficients of Variation (COV), causing reproducibility issues. Shock tubes can address this problem.
Youngbeom Kwon, Yoonkeon Kim, Jongyil Park, Kyoungmin Kim   +3 more
doaj   +1 more source

Single-Pulse Shock Tube Experimental and Kinetic Modeling Study on Pyrolysis of a Direct Coal Liquefaction-Derived Jet Fuel and Its Blends with the Traditional RP-3 Jet Fuel. [PDF]

ACS Omega, 2021
Wang BY, Zeng P, He R, Li F, Yang ZY, Xia ZX, Liang J, Wang QD.   +7 more
europepmc   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source