Results 71 to 80 of about 70,779 (266)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Incident impact of Mach reflection wave configuration at a planar heavy/light interface

Baozha yu Chongji
The evolution of a planar heavy/light gas interface (SF6/N2) subjected to a perturbed shock wave produced by diffracting a planar incident shock over a rigid cylinder is investigated by numerical and theoretical analysis, particularly focusing on the ...
Jingqi GUO, Yizhan LU, Enlai ZHANG, Liyong ZOU   +3 more
doaj   +1 more source

Accurate Hugoniots and sound velocities of bismuth under shock compression in the 38-100 GPa range

AIP Advances, 2018
Dynamic compression experiments of bismuth (Bi) in a shock pressure range of 38-100 GPa were conducted using an explosive drive. The time-resolved particle velocity profiles at the Bi/LiF (lithium fluoride) interface and the impact velocities were ...
Feng Xi, Ke Jin, Huayun Geng, Yinghua Li, Ye Tan, Jun Li, Yi Zhang, Lin Zhang, Lingcang Cai, Yi Sun   +9 more
doaj   +1 more source

Fundamentals of Thermal Transport and Energy Conversion in Ultra‐High Temperature Ceramics: From Microscale Mechanisms to Macroscopic Properties

Advanced Science, EarlyView.
This review critically examines thermal transport and radiative properties of ultra‐high temperature ceramics for hypersonic flight, advanced nuclear systems, and next‐generation energy conversion devices. It explores phonon–photon–electron interactions, microstructural engineering, thermoelectric conversion, and machine learning‐accelerated multiscale
Zhipeng Pei, Yue Li, Jiayu Xing, Yue Zhu, Ru Zhang, Huan Wu, Zihao Qin, Gang Pei, Man Li   +8 more
wiley   +1 more source

Reconfigurable Inflatables Through Controlled Surface Crumpling

Advanced Science, EarlyView.
ABSTRACT Inflatable structures offer remarkable versatility due to their compact storage and rapid deployment, making them ideal for lightweight, quickly assembled, and deployable applications. These structures are typically made from membranes that are nearly inextensible yet highly flexible.
Yi Yang, Hye Jun Youn, Leon Kamp, Renate Sachse, Wenjie Li, Jose Vidal, Jin Feng, Martin Bechthold, Katia Bertoldi   +8 more
wiley   +1 more source

Research Status on Strengthening Mechanism of Particle-reinforced Metal Matrix Composites

Cailiao gongcheng, 2018
The research status on theoretic models and the coupling relationships of Orowan strengthening, dislocation strengthening, load-bearing effect of the reinforcement strengthening and others strengthening are successfully described in this study for ...
YE Xiang-ping, LI Ying-lei, WENG Ji-dong, CAI Ling-cang, LIU Cang-li   +4 more
doaj   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

A Worm‐Inspired Origami Robot with Multimodal Locomotion for Adaptive Mobility in Complex Pipeline Environments

Advanced Science, EarlyView.
An origami worm‐inspired robot achieves multimodal locomotion in confined pipelines through mechatronic integration that embeds actuation, control, and communication within each origami module. Large, reversible configuration and dimensional changes enable 25 gaits synthesized by a unified framework across peristaltic, inchworm, and wheel‐rolling modes
Qiwei Zhang, Kangning Tan, Zihan He, Hongsen Pang, Yanjie Wang, Hongbin Fang, Jian Xu   +6 more
wiley   +1 more source

Measurements of the principal Hugoniots of dense gaseous deuterium−helium mixtures: Combined multi-channel optical pyrometry, velocity interferometry, and streak optical pyrometry measurements

AIP Advances, 2016
The accurate hydrodynamic description of an event or system that addresses the equations of state, phase transitions, dissociations, ionizations, and compressions, determines how materials respond to a wide range of physical environments.
Zhi-Guo Li, Qi-Feng Chen, Yun-Jun Gu, Jun Zheng, Xiang-Rong Chen   +4 more
doaj   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source