Results 61 to 70 of about 4,029,891 (279)

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Dose-related effects of radial extracorporeal shock wave therapy for knee osteoarthritis: A randomized controlled trial

Journal of Rehabilitation Medicine, 2021
Objective: To assess the dose-related effects of radial extracorporeal shock wave therapy on pain alleviation in knee osteoarthritis. Methods: With the use of a 2?×?2 factorial randomized controlled design, 89 patients diagnosed with knee osteoarthritis ...
Ya-Fei Zhang, Yang Liu, Shao-Wen Chou, Hao Weng   +3 more
doaj   +1 more source

Extracorporeal shock wave therapy versus dexamethasone iontophoresis as a treatment for symptomatic knee osteoarthritis

Purpose The goal of this pilot study was to compare and evaluate the efficacy of extracorporeal shock wave therapy (ESWT) and dexamethasone sodium phosphate (DEX-P) iontophoresis in patients who have unilateral symptomatic knee OA (KOA).
Sahar Ahmed Abdalbary, Rania R. Mohamed, Engy Badreldin S. Moustafaa, Mohamed I. Mabrouk, Shimaa Taha Abu El Kasem, Asmaa Abonour   +5 more
core   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Effects of Extracorporeal Shock Wave Therapy on Tendon Integrity, Biomechanical Strength, Matrix Remodeling, Inflammation, Angiogenesis, and Tenogenic Differentiation in Rotator Cuff Injury. [PDF]

Kaohsiung J Med Sci
ABSTRACT Extracorporeal shock wave therapy (ESWT) improves tendon‐bone healing after rotator cuff injury (RCI), but its underlying cellular mechanisms remain unknown. This study aimed to explore the therapeutic effects of ESWT on RCI, with a particular focus on endothelial cells and tenocytes.
Wang H, Wu F, Miao JQ.
europepmc   +2 more sources

Shock wave therapy for lateral elbow pain

Cochrane Database of Systematic Reviews, 2002
This review is one in a series of reviews of interventions for lateral elbow pain.To determine the effectiveness and safety of extracorporeal shock wave therapy (ESWT) for lateral elbow pain.Searches of the Cochrane Controlled Trials Register (Cochrane Library Issue 2, 2004), MEDLINE, EMBASE, CINAHL, and Science Citation Index (SCISEARCH) were ...
R, Buchbinder, S, Green, M, White, L, Barnsley, N, Smidt, W J, Assendelft   +5 more
openaire   +4 more sources

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Shock wave therapy for spastic plantar flexor muscles in hemiplegic cerebral palsy children

Egyptian Journal of Medical Human Genetics, 2015
Background: The spastic motor type is the most common form of cerebral palsy (CP). Spastic equines foot is the most frequent deformity in ambulated children with CP.
Hala A. Abdel Gawad, Amel E. Abdel Karim, Amira H. Mohammed   +2 more
doaj   +1 more source