Results 41 to 50 of about 214,197 (315)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Trade shocks and macroeconomic fluctuations in Africa [PDF]

, 1999
This paper examines the role of external shocks in explaining macroeconomic fluctuations in African countries. We construct a quantitative, stochastic, dynamic, multi-sector equilibrium model of a small open economy calibrated to represent a typical ...
Kose, M. Ayhan, Riezman, Raymond, Riezman, Raymond Glenn   +2 more
core  

THE POSSIBILITY OF FORMING AN EFFECTIVE MECHANISM ATTRACTING FOREIGN INVESTMENTS IN THE ELECTRIC POWER INDUSTRY OF THE RUSSIAN FEDERATION: STRESS TESTING AND REAL OPTIONS METHOD

Вестник университета, 2016
The article considers a challenging issue of creating an effective mechanism for attracting foreign investments in the Russian electric power industry.
Y. Zubkova
doaj  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Social networks and ex post risk management among smallholder farmers in Kenya

Development Studies Research, 2019
Smallholder farmers in developing countries are vulnerable to idiosyncratic and covariate risks. The risks affect their welfare through the shocks they impose on income, assets, health and food supply.
Mercy Mbugua, Jonathan Nzuma, Elijah Muange   +2 more
doaj   +1 more source

Radiative Transfer Modeling of Radio-Band Linear Polarization Observations as a Probe of the Physical Conditions in the Jets of γ-Ray Flaring Blazars

Galaxies, 2016
Since the mid-1980s, the shock-in-jet model has been the preferred paradigm to explain radio-band flaring in blazar jets. We describe our radiative transfer model incorporating relativistically-propagating shocks, and illustrate how the 4.8, 8, and 14.5 ...
Margo F. Aller, Philip A. Hughes, Hugh D. Aller, Talvikki Hovatta, Venkatessh Ramakrishnan   +4 more
doaj   +1 more source

A Shocking Tale

JACC: Case Reports, 2020
[Figure: see text]
openaire   +3 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source