Results 61 to 70 of about 83,391 (283)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Space-vector-modulated three-level inverters with a single Z-source network [PDF]

, 2012
The Z-source inverter is a relatively recent converter topology that exhibits both voltage-buck and voltage-boost capability. The Z-source concept can be applied to all dc-to-ac, ac-to-dc, ac-to-ac, and dc-to-dc power conversion whether two-level or ...
Clare, Jon C., Effah, Francis Boafo, Watson, Alan James, Wheeler, Patrick   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Ex Situ Conservation of Atriplex taltalensis I.M. Johnst. via In Vitro Culturing of Its Axillary Shoots

Diversity, 2022
Atriplex taltalensis is an endangered shrub endemic to northern Chile. Sparse populations of this species can be found in areas with extreme edaphoclimatic conditions in the Atacama desert, and its seeds have a poor germination rate.
Carolina Muñoz-Alcayaga, Jorge Soto, Celián Román-Figueroa, Manuel Paneque   +3 more
doaj   +1 more source

Impedance source interlinking converter for microbial electrosynthesis energy storage applications [PDF]

, 2018
In this paper, a new type of single-stage interlinking converters for Microbial Electrosynthesis (MES) energy storage applications connected to the three-phase grid is presented, in which impedance source network (ZSN) is employed to reduce cost and ...
Luna Alloza, Álvaro, Muñoz, Raul Santiago, Rocabert Delgado, Joan, Rodríguez Cortés, Pedro, Shahparasti, Mahdi   +4 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Micropropagation of Plantago asiatica L. through culture of shoot-tips

Acta Societatis Botanicorum Poloniae, 2011
Shoot-tip multiplication of the medicinal species - Plantago asiatica was carried on MS medium with IAA and BAP or kinetin. Best results in micropropagation were achieved by adding 0.1 mg/dm3 IAA and 1 mg/dm3 BAP. After 6 weeks shoots were transferred to
Joanna Makowczyńska, Emilia Andrzejewska-Golec   +1 more
doaj   +1 more source

EFFORTS TO IMPROVE FUTSAL SHOOTING THROUGH GAME VARIATIONS

Gladi : Jurnal Ilmu Keolahragaan
This research is action research to improve shooting skills in futsal games in class V and VI students who are registered as futsal extracurricular participants at SDN Srengseng Sawah 04 with a total of 53 students as subjects. This action research uses the Kemmis Taggart model which consists of two cycles. The actions in this research use a variety of
Yusuf, Ramdan Muhammad, Sujarwo, Setiakarnawijaya, Yasep   +2 more
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source