Results 291 to 300 of about 1,030,038 (390)

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

open access: yesAdvanced Science, EarlyView.
The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino   +20 more
wiley   +1 more source

HSFA2D-LAZY6-LAZY1 module regulates shoot gravitropism and tiller angle in rice. [PDF]

open access: yesNew Phytol
Liang Y   +12 more
europepmc   +1 more source

Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long‐Term Neuroprotection After Traumatic Brain Injury in Mice

open access: yesAdvanced Science, EarlyView.
Pischiutta F and coworkers identify prostaglandins and kynurenine as key mediators of the mesenchymal stromal cells‐derived secretome's neuroprotective effects. A synthetic cocktail composed of these factors promotes long‐term functional recovery, reduces brain structural damage, and modulates neuroinflammation after traumatic brain injury, supporting ...
Francesca Pischiutta   +24 more
wiley   +1 more source

Forage Crop Research in the Modern Age

open access: yesAdvanced Science, EarlyView.
Forage crops are increasingly vital to sustainable agriculture, yet urgent demands for transformative innovations create unprecedented opportunities and challenges. This review synthesizes the latest advances in forage research, spotlighting cutting‐edge breeding technologies and their transformative potential.
Qikun Liu   +11 more
wiley   +1 more source

JA‐Mediated Regulation of Amino Acid Homeostasis Adjusts Metabolic Flux and Enhances Spider Mite Tolerance via the SlJAZ8‐SlWRKY57‐SlAVT6s Module in Tomato

open access: yesAdvanced Science, EarlyView.
This study elucidates a novel SlJAZ8‐SlWRKY57‐SlAVT6A/SlAVT6B module that effectively channels metabolic flux from primary to secondary metabolism, impacting plant growth, development, and resistance. Two novel vacuolar amino acid exporters, SlAVT6A and SlAVT6B, fine‐tunes trichomes, terpenes, and gibberellins, bolstering spider mite resistance.
Yingchen Hao   +11 more
wiley   +1 more source

Root growth and branching are enabled by brassinosteroid-regulated growth anisotropy and carbon allocation. [PDF]

open access: yesNat Commun
Khandal H   +7 more
europepmc   +1 more source

Adducin‐1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity

open access: yesAdvanced Science, EarlyView.
In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang   +10 more
wiley   +1 more source

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