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Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source

Stacking for Probabilistic Short-Term Load Forecasting

In this study, we delve into the realm of meta-learning to combine point base forecasts for probabilistic short-term electricity demand forecasting. Our approach encompasses the utilization of quantile linear regression, quantile regression forest, and post-processing techniques involving residual simulation to generate quantile forecasts. Furthermore,
openaire +3 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source

Trend estimation and short-term forecasting of COVID-19 cases and deaths worldwide [PDF]

Proc Natl Acad Sci U S A, 2022
Krymova E +9 more
europepmc +2 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source

Seasonal dynamic factor analysis and bootstrap inference : application to electricity market forecasting [PDF]

Year-ahead forecasting of electricity prices is an important issue in the current context of electricity markets. Nevertheless, only one-day-ahead forecasting is commonly tackled up in previous published works.
Carolina Garcia-Martos +3 more
core

Statistical Approaches to Short-term Electricity Forecasting [PDF]

, 2008
Andrea Kellová Statistical Approaches to Short-term Electricity Forecasting Abstrakt v češtině - dokument ...
Kellová, Andrea
core

Short-term wind speed forecasting using an optimized three-phase convolutional neural network fused with bidirectional long short-term memory network model [PDF]

Wind energy is an environment friendly, low-carbon, and cost-effective renewable energy source. It is, however, difficult to integrate wind energy into a mixed energy grid due to its high volatility and intermittency.
Deo, Ravinesh C. +5 more
core +1 more source

Short-Term Forecasting of Monkeypox Cases Using a Novel Filtering and Combining Technique. [PDF]

Diagnostics (Basel), 2023
Iftikhar H, Khan M, Khan MS, Khan M.
europepmc +1 more source

short term load forecasting
short-term load forecasting
forecasting