Results 81 to 90 of about 8,462,031 (305)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Multi-Model Prediction for Demand Forecast in Water Distribution Networks
Energies, 2018 This paper presents a multi-model predictor called Qualitative Multi-Model Predictor Plus (QMMP+) for demand forecast in water distribution networks. QMMP+ is based on the decomposition of the quantitative and qualitative information of the time-series ...
Rodrigo Lopez Farias +3 more
doaj +1 more source
Improving the Short-Term Prediction of Suicidal Behavior [PDF]
, 2017 Aspirational Goal 3 of the National Action Alliance for Suicide Prevention’s Research Prioritization Task Force is to predict who is at risk for attempting suicide in the near future.
Nock, Matthew, Glenn, Catherine R.
core +1 more source
jiaxiang-cheng/PyTorch-LSTM-for-RUL-Prediction: LSTM for RUL Prediction
, 2021 PyTorch implementation of remaining useful life prediction with long-short term memories (LSTM), performing on NASA C-MAPSS data sets. Partially inspired by Zheng, S., Ristovski, K., Farahat, A., & Gupta, C. (2017, June).
Jia-Xiang Cheng
core +1 more source
A neural network model for short term river flow prediction [PDF]
Natural Hazards and Earth System Sciences, 2006 This paper presents a model using rain gauge and weather radar data to predict the runoff of a small alpine catchment in Austria. The gapless spatial coverage of the radar is important to detect small convective shower cells, but managing such a huge ...
R. Teschl, W. L. Randeu
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Short-Term and Long-Term Travel Time Prediction Using Transformer-Based Techniques
Applied SciencesIn the evolving field of Intelligent Transportation Systems (ITSs), accurate and reliable traffic prediction is essential in enhancing management and planning capabilities.
Hui-Ting Christine Lin +2 more
doaj +1 more source
A method for foF2 short-term prediction
Physics and Chemistry of the Earth, Part C: Solar, Terrestrial & Planetary Science, 2000 A method for foF2 short-term prediction with 1–24 hour lead times is proposed. It is based on ΔfoF2 (deviation of hourly foF2 from running median) regression with the previous ΔfoF2 observations and hourly spline-interpolated daily Ap index. An optimum training time interval of 25–30 days, which is close to one solar rotation, has been revealed.
Marín Santos, Diego +2 more
openaire +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source