Results 91 to 100 of about 334,674 (285)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Influence of Rail Welds in Steel Spring Floating Slab Track on the Wheel-Rail Dynamic Response

Chengshi guidao jiaotong yanjiu
ObjectiveRail joint welds can adversely affect vehicles and tracks, necessitating research into the influence of rail welds on the wheel-rail dynamic response of floating slab tracks.
Anyang WANG, Xia LI, Hu TANG, Anbin WANG
doaj   +1 more source

Soft QGP probes with ALICE

, 2016
In heavy-ion collisions at the LHC a hot and dense medium of deconfided partons, the Quark-Gluon Plasma (QGP), is created. Its global properties can be characterized by the measurements of particles in the low transverse momentum (or "soft") regime ...
Graczykowski, Łukasz Kamil
core   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Vapor Phase Deposition of Perovskite Photovoltaics: Short Track to Commercialization? [PDF]

Energy & Environmental Science
While perovskite-based photovoltaics (PV) is progressing toward commercialization, it remains an open question which fabrication technology - solution-based, vapor-based, or combinations - will pave the way to faster economic breakthrough. The vast majority of research studies make use of solution-processed perovskite thin films, which benefit from ...
Abzieher, Tobias, Moore, David, Roß, Marcel, Albrecht, Steve, Silvia, Jared, Tan, Hairen, Jeangros, Quentin, Ballif, Christophe, Hoerantner, Maximilian, Chiang, Yu-Hsien, Kim, Beom-Soo, Bolink, Henk, Pistor, Paul, Goldschmidt, Jan Christoph, Chiang, Yu-Hsien, Stranks, Samuel, Borchert, Anna Juliane, McGehee, Michael, Morales-Masis, Monica, Patel, Jay, Bruno, Annalisa, Paetzold, Ulrich   +21 more
openaire   +6 more sources

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Keeping track of hidden dangers - The short history of the Sabiá virus

Revista da Sociedade Brasileira de Medicina Tropical
Emerging infectious diseases are a global threat. In countries like Brazil, where biodiversity is high and public health conditions in terms of infrastructure and medical care are often precarious, emerging diseases are particularly worrisome.
Joel Henrique Ellwanger, José Artur Bogo Chies   +1 more
doaj   +1 more source

Selective Ensemble Mean Technique for Tropical Cyclone Track Forecasts Using Multi-Model Ensembles

Tropical Cyclone Research and Review, 2015
: A selective ensemble mean technique for tropical cyclone (TC) track forecasts, which excludes from the ensemble those models that have large position errors at short lead times, was applied to a set of TC track forecasts produced by 11 operational ...
Masato Nishimura, Munehiko Yamaguchi
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source