Results 61 to 70 of about 4,914,687 (326)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs

BMC Research Notes, 2012
Background Interposition of a reversed jejunal loop in short bowel sydrome has previously been investigated in human along with animal models and seemed able to facilitate intestinal adaptation.
Papamichail Michail, Digalakis Michail, Panagiotis Prigouris, Paisios Odysseas, Loti Soyltana, Sergentanis Theodoros   +5 more
doaj   +1 more source

Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome

Frontiers in Physiology, 2017
Short bowel syndrome (SBS) is characterized by severe intestinal malabsorption following restrictive surgery. The objective of this study was to determine the functional contribution of SBS-microbiota after resection. It is well-known that SBS-microbiota
L. Gillard, C. Mayeur, V. Robert, Isabelle Pingenot, J. Le Beyec, A. Bado, P. Lepage, Muriel Thomas, F. Joly   +8 more
semanticscholar   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Surgical Management of Inguinal Hernias at Bugando Medical Centre in Northwestern Tanzania: Our Experiences in a Resource-Limited Setting. [PDF]

, 2012
Inguinal hernia repair remains the commonest operation performed by general surgeons all over the world. There is paucity of published data on surgical management of inguinal hernias in our environment.
AN Kingsnorth, AR Adesunkanmi, C Schutz, D Maggiore, D Watkin, DC Lewis, DL Crawford, EM Nordberg, ES Garba, EU Hernia Trialists Collaboration, EU Hernia Trialists Collaboration, IG Schools, IL Lichtenstein, IM Rutkow, IVA Nesterenko, JA Álvarez, JD Nathan, Joseph B Mabula, M Baloch, M Ohene-Yeboah, M Ohene-Yeboah, ME McFarlane, MR Gulzar, N Ali, N Mbah, NS Williams, OA Awoyobi, OD Osifo, P Lal, P Primatesta, P Sanjay, Phillipo L Chalya, S Post, S Rai, SD Berliner, SR Menakuru, T Fasih, U Wolters, VM Kimyil   +38 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Perianastomotic ulceration in children with short bowel syndrome

Journal of Pediatric Surgery Case Reports, 2022
Objectives: Perianastomotic ulceration (PAU) is an uncommon but potentially devastating condition, with a wide range of presenting symptoms. However, treatment approaches differ between centres as they are well known to be difficult to treat, and ...
Yvonne Chi-Lun Leung, Paula Man-Yee Tang, Nicholas Shih-Yin Chao, Michael Wai-Yip Leung   +3 more
doaj   +1 more source

Pelvic floor muscle training for secondary prevention of pelvic organ prolapse (PREVPROL): a multicentre randomised controlled trial [PDF]

, 2017
BackgroundPelvic floor muscle training can reduce prolapse severity and symptoms in women seeking treatment. We aimed to assess whether this intervention could also be effective in secondary prevention of prolapse and the need for future treatment ...
Collins, Marissa, Dickson, Sylvia, Elders, Andrew, Glazener, Cathryn, Hagen, Suzanne, Hay-Smith, Jean, Hemming, Christine, Herbison, Peter, Logan, Janet, Macarthur, Christine, McClurg, Doreen, Toozs-Hobson, Philip, Wilson, Don   +12 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A new surgical technique for short bowel syndrome

BMC Surgery, 2022
Objective Short bowel syndrome (SBS) is a severe intestinal disease that causes malabsorption. Long-term parental nutrition therapy induces infection and liver failure.
Isamu Saeki, Sho Kurihara, Masato Kojima, Hiroki Ohge, Shinya Takahashi, Eiso Hiyama   +5 more
doaj   +1 more source