Results 41 to 50 of about 4,480,870 (245)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The comparison of the intestinal adaptation effects of subcutaneous and oral insulin in a rats with short bowel syndrome

African Journal of Paediatric Surgery, 2013
Aim: Insulin has been reported to have positive effects on intestinal adaptation after short bowel syndrome when applicated oral or subcutaneously. The purpose of this study is to compare the intestinal adaptation effects of subcutaneous and oral routes ...
Unal Bicakci, Ozgur K Tuncel, Birsen Bilgici, Burak Tander, Ender Ariturk, Riza Rizalar, Omer Alici, Ferit Bernay   +7 more
doaj   +1 more source

The effect of probiotics on ıntestinal motility in an experimental short bowel model [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose To investigate the effect of probiotics on spontaneous contractions of smooth muscle isolated from jejunum and ileum of rat model. Methods Four rat groups were created (n=8, in each) including control (Group 1), control+probiotic (Group 2 ...
Mehmet Metin, Ahmet Altun, Gökhan Köylüoğlu   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Re-tubularization of highly-ischemic anti-mesenteric border (ReHAB)

Journal of Pediatric Surgery Case Reports, 2021
Complex gastroschisis and other etiologies of intestinal compromise present a difficult medical and surgical challenge in the neonatal and pediatric population.
Joseph J. Lopez, Richard J. Hendrickson
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Congenital short bowel syndrome: a rare cause of neonatal intestinal obstruction

Journal of International Medical Research, 2020
Congenital short bowel syndrome (CSBS) is an uncommon gastrointestinal disorder in which an unclear aetiology causes considerable intrauterine reduction in small bowel length.
Mostafa Zain, Mansour Abdelkader, Ahmed Azab, Mostafa Kotb   +3 more
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Management of irritable bowel syndrome in primary care: feasibility randomised controlled trial of mebeverine, methylcellulose, placebo and a patient self-management cognitive behavioural therapy website (MIBS trial) [PDF]

, 2010
Background: IBS affects 10-22% of the UK population. Abdominal pain, bloating and altered bowel habit affectquality of life, social functioning and time off work.
Tapp Laura, Everitt, Hazel A., Everitt Hazel A, Smith Peter W, Laura Tapp, Alice Sibelli, Lucy Yardley, Coleman Nicholas S, Moss-Morris Rona E, Rona E Moss-Morris, Smith, Peter W., Nicholas S Coleman, Moss-Morris, Rona E., Hazel A Everitt, Yardley, Lucy, Tapp, Laura, Paul S Little, Yardley Lucy, Sibelli, Alice, Little, Paul S., Coleman, Nicholas S., Peter W Smith, Sibelli Alice, Little Paul S   +23 more
core   +2 more sources