Results 1 to 10 of about 1,560,381 (192)

Inositol hexaphosphate promotes intestinal adaptation in short bowel syndrome via an HDAC3-mediated epigenetic pathway [PDF]

Food & Nutrition Research, 2023
Background: Short bowel syndrome (SBS) has high morbidity and mortality rates, and promoting intestinal adaptation of the residual intestine is a critical treatment.
Weipeng Wang, Ying Wang, Ying Lu, Xinbei Tian, Shanshan Chen, Bo Wu, Jun Du, Yongtao Xiao, Wei Cai   +8 more
doaj   +2 more sources

Intestinal Adaptation upon Chemotherapy-Induced Intestinal Injury in Mice Depends on GLP-2 Receptor Activation [PDF]

Biomedicines, 2021
Intestinal adaptation is an important response and a natural repair mechanism in acute intestinal injury and is critical for recovery. Glucagon-like peptide 2 (GLP-2) has been demonstrated to enhance mucosal repair following intestinal damage.
Anna Billeschou, Jenna Elizabeth Hunt, Aruna Ghimire, Jens J. Holst, Hannelouise Kissow   +4 more
doaj   +2 more sources

Biological Insights into Intestinal Adaptation from Preclinical Models of Short Bowel Syndrome [PDF]

Cells
Short bowel syndrome is a rare and clinically heterogeneous condition resulting from extensive intestinal resections or functional impairment, leading to malabsorption, fluid and electrolyte losses, and potential progression to intestinal failure ...
Cesare Pane, Pierluigi Puca, Miriam Di Mattia, Sara Troisi, Marianna Kashyrina, Marco Pizzoferrato, Letizia Masi, Laura Parisio, Maria Cristina De Rosa, Beatrice Scagnoli, Marcello Chieppa, Valentina Petito, Loris Riccardo Lopetuso, Franco Scaldaferri, Alfredo Papa   +14 more
doaj   +2 more sources

Host-Gut Microbiota Crosstalk in Intestinal AdaptationSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2018
Short-bowel syndrome represents the most common cause of intestinal failure and occurs when the remaining intestine cannot support fluid and nutrient needs to sustain adequate physiology and development without the use of supplemental parenteral ...
Justine Marchix, Gillian Goddard, Michael A. Helmrath   +2 more
doaj   +2 more sources

Xenotransplanted human organoids identify transepithelial zinc transport as a key mediator of intestinal adaptation [PDF]

Nature Communications
Short bowel syndrome (SBS) leads to severe morbidity and mortality. Intestinal adaptation is crucial in improving outcomes. To understand the human gene pathways associated with adaptation, we perform single-cell transcriptomic analysis of human small ...
Maame Efua S. Sampah, Hannah Moore, Raheel Ahmad, Johannes Duess, Peng Lu, Carla Lopez, Steve Steinway, Daniel Scheese, Zachariah Raouf, Koichi Tsuboi, Jeffrey Ding, Connor Caputo, Madison McFarland, William B. Fulton, Sanxia Wang, Meghan Wang, Thomas Prindle, Vered Gazit, Deborah C. Rubin, Samuel Alaish, Chhinder P. Sodhi, David J. Hackam   +21 more
doaj   +2 more sources

Lactobacillus rhamnosus GG maintains gut microbiota stability and promotes intestinal adaptation via activated intestinal farnesoid X receptor signaling in short bowel syndrome [PDF]

Communications Biology
Intestinal farnesoid X receptor (FXR) signaling plays a critical role in maintaining intestinal microbiota stability. In this study, we investigated the probiotic Lactobacillus rhamnosus GG (LGG) and its ability to promote intestinal adaptation and ...
Linling Gui, Xufei Duan, Hanfei Wang, Hua Xie, Ruyi Zhang, Weiwei Jiang, Weibing Tang   +6 more
doaj   +2 more sources

Dietary polyamines promote intestinal adaptation in an experimental model of short bowel syndrome [PDF]

Scientific Reports
Intestinal adaptation does not necessarily recover absorptive capacity in short bowel syndrome (SBS), sometimes resulting in intestinal failure-associated liver disease (IFALD). Additionally, its therapeutic options remain limited. Polyamines (spermidine
Naoya Kasahara, Takumi Teratani, Shinichiro Yokota, Yasunaru Sakuma, Hideki Sasanuma, Yasuhiro Fujimoto, Tetsuo Ijichi, Taizen Urahashi, Hideyuki Yoshitomi, Joji Kitayama, Naohiro Sata   +10 more
doaj   +2 more sources

Glutamine and Pediatric Intestinal Barrier Function: A Scoping Review of Clinical Evidence and Research Gaps [PDF]

Children
Background/Objectives: Glutamine has been proposed as a nutritional modulator of intestinal epithelial integrity, but its effects on intestinal barrier function in children remain uncertain.
Dejan Dobrijević, Nataša Nastić, Kristian Pastor   +2 more
doaj   +2 more sources

Mechanosensitive ion channels in intestinal homeostasis and disease [PDF]

eGastroenterology
Mechanical deformation is integral to intestinal physiology, linking luminal transit to epithelial adaptation and motor control. These physical cues engage multiple mechanotransduction pathways that coordinate cellular adaptation and help preserve ...
Hong Yang, Xiaoyin Bai, Yubin Cao, Nan Ma, Xiaowei Xue, Hanqiao Dai, Qi Rao, Wenzhong Li, Lingjuan Jiang   +8 more
doaj   +2 more sources

Altered fecal microbiome and metabolome profiles in rat models of short bowel syndrome

Frontiers in Microbiology, 2023
IntroductionShort bowel syndrome (SBS) is featured by impaired nutrients and fluids absorption due to massive small intestine resection. Gut dysbiosis has been implicated in SBS, this study aimed to characterize the metagenomic and metabolomic profiles ...
Yuhua Huang, Jian Jiao, Danhua Yao, Feilong Guo, Yousheng Li   +4 more
doaj   +1 more source