Results 81 to 90 of about 55,448 (270)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Introduction of universal transvaginal cervical length measurement does not decrease spontaneous preterm delivery rate compared to universal transabdominal screening with reflex cut‐off: A pre‐post study

iRADIOLOGY
Objectives The objective of our study is to examine cervical length measurements, identification of short cervix, vaginal progesterone use, and rate of spontaneous preterm delivery before and after departmental transition to a universal transvaginal ...
Emily Holthaus, Layan Alrahmani, Nicole Sprawka, Jean Ricci Goodman, Ann Lal   +4 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

A predictive model of short cervix at 20-24 weeks using first-trimester cervical length measurement and maternal history

, 2011
OBJECTIVES: To develop a model for the prediction of short cervix (
Michalitsi, V., Papastefanou, I., Kassanos, D., Papadopoulos, G. K., Souka, A. P.   +4 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Ultrasound-indicated cerclage: does expedited placement prolong gestation?AJOG Global Reports at a Glance

AJOG Global Reports
Background: There is no clear consensus on the urgency of ultrasound-indicated cerclage placement after sonographic diagnosis of a short cervix, and it remains uncertain whether immediate cerclage placement prolongs gestation and improves pregnancy ...
Sarah H. Abelman, MD, Frank I. Jackson, DO, Nathan A. Keller, MD, Julie Chen, BBA, Luis A. Bracero, MD, Cara S. Wetcher, MD, Matthew J. Blitz, MD, MBA   +6 more
doaj   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Relation of cervical length at 22-24 weeks of gestation to demographic characteristics and obstetric history

Brazilian Journal of Medical and Biological Research, 2004
Preterm delivery is the main cause of neonatal death and ultrasonographic cervical assessment has been shown to be more accurate than digital examination in recognizing a short cervix.
Palma-Dias R.S., Fonseca M.M., Stein N.R., Schmidt A.P., Magalhães J.A.   +4 more
doaj  

Implementation protocol for a treatment bundle targeting modifiable risk factors for preterm birth

Global Health Action
Preterm birth (PTB) is the main cause of perinatal and neonatal morbidity and mortality worldwide. Widespread implementation of guidelines for early identification and management of patients at risk for adverse pregnancy outcomes is still feeble.
Gabrieli Roque de Castro, Bianca Milani Biazotto, Isabela Rodrigues da Silva, Gabriela Goes Herrera, Júlia Nepomucena Ruiz, Beatriz Marques Pizzinato, Karoline de Campos, Ana Lissa Camargo Pedroso, Alice Alves Gimenez, Nathália Lima Araújo Nunes, Gabriele Fernanda Oliveira Silva, Elis Marina Turini Claro, Natália Lucatto Vicaro, Ramkumar Menon, Rodolfo de Carvalho Pacagnella, Márcia Guimarães da Silva, João José Aguera Oliver Júnior, Bruna Ribeiro de Andrade Ramos   +17 more
doaj   +1 more source