Ultraaccurate genome sequencing and haplotyping of single human cells. [PDF]
, 2017 Accurate detection of variants and long-range haplotypes in genomes of single human cells remains very challenging. Common approaches require extensive in vitro amplification of genomes of individual cells using DNA polymerases and high-throughput short ...
Bafna, Vineet +6 more
core +1 more source
An Improved Genome Assembly of Azadirachta indica A. Juss.
G3: Genes, Genomes, Genetics, 2016 Neem (Azadirachta indica A. Juss.), an evergreen tree of the Meliaceae family, is known for its medicinal, cosmetic, pesticidal and insecticidal properties.
Neeraja M. Krishnan +4 more
doaj +1 more source
CRISPR/Cas9-mediated gene manipulation to create single-amino-acid-substituted and floxed mice with a cloning-free method. [PDF]
, 2017 Clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology is a powerful tool to manipulate the genome with extraordinary simplicity and speed.
Chen, Chao +6 more
core +3 more sources
PuFFIN--a parameter-free method to build nucleosome maps from paired-end reads. [PDF]
, 2014 BackgroundWe introduce a novel method, called PuFFIN, that takes advantage of paired-end short reads to build genome-wide nucleosome maps with larger numbers of detected nucleosomes and higher accuracy than existing tools. In contrast to other approaches
Bunnik, Evelien M +3 more
core +4 more sources
Nature Communications, 2020 The complexity of structural variation (SV) and short tandem repeats (STRs) makes it necessary to apply different calling and filtering strategies to sequencing datasets. Here, Jakubosky et al.
David Jakubosky +11 more
doaj +1 more source
A Short Report on the Markov Property of DNA Sequences on 200-bp Genomic Units of Roadmap Genomics ChromHMM Annotations: A Computational Perspective [PDF]
Genomics & Informatics, 2018 The non-coding DNA in eukaryotic genomes encodes a language that programs chromatin accessibility, transcription factor binding, and various other activities. The objective of this study was to determine the effect of the primary DNA sequence on the epigenomic landscape across a 200-base pair of genomic units by integrating 127 publicly available ...
openaire +3 more sources
Highlights of the 2nd Bioinformatics Student Symposium by ISCB RSG-UK [version 1] [PDF]
, 2016 Following the success of the 1 (st) Student Symposium by ISCB RSG-UK, a 2 (nd) Student Symposium took place on 7 (th) October 2015 at The Genome Analysis Centre, Norwich, UK. This short report summarizes the main highlights from the 2 (nd) Bioinformatics
Das, S +5 more
core +1 more source
Genome sequence of the white-rot fungus Irpex lacteus F17, a type strain of lignin degrader fungus
Standards in Genomic Sciences, 2017 Irpex lacteus, a cosmopolitan white-rot fungus, degrades lignin and lignin-derived aromatic compounds. In this study, we report the high-quality draft genome sequence of I.
Mengwei Yao +4 more
doaj +1 more source
Chromosome-scale assembly and annotation of the perennial ryegrass genome
BMC Genomics, 2022 Background The availability of chromosome-scale genome assemblies is fundamentally important to advance genetics and breeding in crops, as well as for evolutionary and comparative genomics.
Istvan Nagy +7 more
doaj +1 more source
11p15.4 Microdeletion Associates with Hemihypertrophy
Case Reports in Genetics, 2018 We report a preterm female infant with intrauterine growth retardation, dysmorphic facies, missing rib, small hands and feet, and hemihypertrophy. The results of whole genome SNP microarray analysis showed approximately 77 Kb interstitial deletion of the
Surasak Puvabanditsin +6 more
doaj +1 more source