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How viral proteins bind short linear motifs and intrinsically disordered domains
Essays in Biochemistry, 2022Abstract Viruses are the obligate intracellular parasites that exploit the host cellular machinery to replicate their genome. During the viral life cycle viruses manipulate the host cell through interactions with host proteins. Many of these protein–protein interactions are mediated through the recognition of host globular domains by ...
Priyanka Madhu +2 more
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Screening Intrinsically Disordered Regions for Short Linear Binding Motifs
2020The intrinsically disordered regions of the proteome are enriched in short linear motifs (SLiMs) that serve as binding sites for peptide binding proteins. These interactions are often of low-to-mid micromolar affinities and are challenging to screen for experimentally.
Muhammad, Ali +2 more
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Stressing the role of a short linear motif in ataxin-2 condensation
Molecular Cell, 2023Ataxin-2, an RNA-binding protein that is conserved across eukaryotes, is involved in stress granule assembly and age-associated neurodegenerative diseases. In this issue of Molecular Cell, Boeynaems et al.1 identify a short linear motif in ataxin-2 as a condensation switch, providing molecular insights into its essential role in cellular stress ...
Scheidt, Tom +3 more
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Prediction of Biological Protein-protein Interaction Types Using Short-Linear Motifs
Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical Informatics, 2013Protein-protein interactions (PPIs) play a key role in many biological processes and functions in living cells. Thus, identification, prediction, and analysis of PPIs are important aspects in molecular biology. We propose a computational model to predict biological PPI types using short-linear motifs (SLiMs).
Manish Pandit, Luis Rueda, Alioune Ngom
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Identifying Protein Short Linear Motifs by Position-Specific Scoring Matrix
2016Short linear motifs (SLiMs) play a central role in several biological functions, such as cell regulation, scaffolding, cell signaling, post-translational modification, and cleavage. Identifying SLiMs is an important step for understanding their functions and mechanism.
Chun Fang +3 more
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Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication
Molecular Cell, 2021Manzar J Hossain +2 more
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Do short, frequent DNA sequence motifs mould the epigenome?
Nature Reviews Molecular Cell Biology, 2016Adrian Peter Bird
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Degrons and degradation signals beyond short linear motifs
Nature Chemical BiologyBaiyun Wang, Ning Zheng
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