Results 41 to 50 of about 2,079,436 (269)

The integrated approach to the assessment of the functional state of highly skilled sportsmen of endurance sports in the preparatory period

open access: yesСпортивная медицина: наука и практика, 2020
Objective: to evaluate the functional state of cardio, neuro-endocrine and central nervous systems of highly skilled sportsmen of endurance sports under specific load.
T. Bruk   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Using the principal model in the preparation of athletes qualified in short-track [PDF]

open access: yesPedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2011
The materials on the level of development problems of modeling training process in short-track. Analysis of materials preparation and construction of the training process and a change of the training loads. Constructed basic model training process. Shown
Kugaevskij Sergej Aleksandrovich
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Nuclear emulsion measurements of the astronauts' radiation exposures on Skylab missions 2, 3, and 4 [PDF]

open access: yes
On the Skylab missions, Ilford G.5 and K.2 emulsions were flown as part of passive dosimeter packs carried by the astronauts on their wrists. Due to the long mission times, latent image fading and track crowing imposed limitations on a quantitative track
Schaefer, H. J., Sullivan, J. J.
core   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Evaluating Short-Wave Effects in Railway Track Using the Rail Surface Signal

open access: yesApplied Sciences, 2022
Condition assessment and maintenance planning of railway infrastructure is a prerequisite for safe and reliable train operation. As the loads are constantly increasing, condition assessment of the track must also be further developed.
Markus Loidolt, Stefan Marschnig
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Relieving the Wireless Infrastructure: When Opportunistic Networks Meet Guaranteed Delays [PDF]

open access: yes, 2011
Major wireless operators are nowadays facing network capacity issues in striving to meet the growing demands of mobile users. At the same time, 3G-enabled devices increasingly benefit from ad hoc radio connectivity (e.g., Wi-Fi).
Conan, Vania   +4 more
core   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

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