Results 41 to 50 of about 2,092,187 (288)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Measuring, Predicting and Visualizing Short-Term Change in Word Representation and Usage in VKontakte Social Network

open access: yes, 2017
Language in social media is extremely dynamic: new words emerge, trend and disappear, while the meaning of existing words can fluctuate over time. Such dynamics are especially notable during a period of crisis. This work addresses several important tasks
Arendt, Dustin   +3 more
core   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

An Intelligent Track Segment Association Method Based on Characteristic-Aware Attention LSTM Network

open access: yesSensors
Accurate track segment association plays an important role in modern sensor data processing systems to ensure the temporal and spatial consistency of target information.
Jiadi Qi, Xiaoke Lu, Jinping Sun
doaj   +1 more source

The integrated approach to the assessment of the functional state of highly skilled sportsmen of endurance sports in the preparatory period

open access: yesСпортивная медицина: наука и практика, 2020
Objective: to evaluate the functional state of cardio, neuro-endocrine and central nervous systems of highly skilled sportsmen of endurance sports under specific load.
T. Bruk   +4 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Using the principal model in the preparation of athletes qualified in short-track [PDF]

open access: yesPedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2011
The materials on the level of development problems of modeling training process in short-track. Analysis of materials preparation and construction of the training process and a change of the training loads. Constructed basic model training process. Shown
Kugaevskij Sergej Aleksandrovich
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Content-based access to digital video: the Físchlár system and the TREC video track [PDF]

open access: yes, 2001
This short paper presents an overview of the Físchlár system - an operational digital library of several hundred hours of video content at Dublin City University which is used by over 1,000 users daily, for a variety of applications.
Smeaton, Alan F.
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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