Results 41 to 50 of about 114,922 (215)

Medicine shortages: impact behind numbers

Journal of Pharmaceutical Policy and Practice, 2023
Introduction Current research to assess the impact that medicine shortages have on patients is limited to general aspects, such as the prevalence of shortages and product characteristics.
Doerine J. Postma, Kim Notenboom, Peter A. G. M. De Smet, Hubert G. M. Leufkens, Aukje K. Mantel-Teeuwisse   +4 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Pharmacists’ approach to oncology medicine shortages: results of a cross-sectional survey in Pakistan

BMJ Open, 2023
Objectives The study estimated the shortages of oncology medicines in Pakistan, their causes, impacts, mitigation strategies, and possible interventions.Design Cross-sectional survey.Setting Oncology pharmacists working at 43 oncology settings (out of 80)
Caijun Yang, Faiz Ullah Khan, Yu Fang, Sundus Shukar, Muhammad Hassaan Shahid, Jinwei Zhang, Shayan Muhammad Din   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

The impact of the European Medicines Agency (EMA) and the Heads of Medicines Agencies (HMA) to address shortages of human and veterinary medicines across Europe

Frontiers in Public Health
Shortages of medicines are a global public health challenge with a significant impact on patient care. While the issue is at the top of the agenda of EU policymakers, regulators and healthcare providers, shortages are a complex problem with many ...
Inga Abed, Vanessa Bennett, Brendan Cuddy, Sandra Dang, Juan García Burgos, Domenico Di Giorgio, Maria Lamas, Momir Radulovic, Nuno Simões, Rui Santos Ivo, Hugues Malonne, Monica Dias   +11 more
doaj   +1 more source

Impact of medicine shortages on patients - a framework and application in the Netherlands

BMC Health Services Research, 2022
Background Medicine shortages are often described in plain numbers, suggesting all shortages have a uniform impact. However, some shortages have a direct and serious effect on patients and need a prompt reaction from stakeholders.
Doerine J. Postma, Peter A. G. M. De Smet, Kim Notenboom, Hubert G. M. Leufkens, Aukje K. Mantel-Teeuwisse   +4 more
doaj   +1 more source

Community Pharmacy Staff Knowledge, Opinion and Practice toward Drug Shortages in Saudi Arabia

Saudi Pharmaceutical Journal, 2021
Drug shortages continue to pose a significant threat to public health and safety. Drug shortages not only worsen patient outcomes, but also significantly burden healthcare systems with additional costs. This study aimed to assess community pharmacy staff
Mona Y. Alsheikh, Maram A. Alzahrani, Norah A. Alsharif, Hadeel M. Altowairqi, Shahad A. Asiri, Bushra M. Althubaiti, Ali M. Alshahrani, Ahmed I. Fathelrahman, Moudi M. Alasmari, Amal F. Alotaibi   +9 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source