Results 51 to 60 of about 524,063 (295)

An investigation of shortest paths algorithms [PDF]

open access: yes, 1987
In this work, we classify the shortest path problems, review all source algorithms and analyse the different implementations of single source algorithms using various list structures and labelling techniques.
Tabatabai, Bijan Oni, Tabatabai, B.O
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Associative Parallel Algorithm for Dynamic Update of the Shortest Paths Tree

open access: yesМоделирование и анализ информационных систем, 2013
The paper proposes an efficient associative algorithm for dynamic update of the shortest paths tree of a directed weighted graph after deleting an edge.
A. S. Nepomniaschaya
doaj   +3 more sources

A genetic algorithm for finding the k shortest paths in a network

open access: yesEgyptian Informatics Journal, 2010
Most of the multimedia applications require the k shortest paths during the communication between a single source and multiple destinations. This problem is known as multimedia multicast routing and has been proved to be NP-complete. The paper proposes a
Ahmed Younes Hamed
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

A Constrained Time-Dependent K Shortest Paths Algorithm Addressing Overlap and Travel Time Deviation

open access: yesInternational Journal of Transportation Science and Technology, 2015
Theoretical research often assumes all users are homogeneous in their route choice decision and will always pick the route with the shortest travel cost, which is not necessarily the case in reality. This paper documents the research effort in developing
Xianbiao Hu, PhD, Yi-Chang Chiu
doaj   +1 more source

The Discrepancy of Shortest Paths

open access: yesCoRR
The hereditary discrepancy of a set system is a certain quantitative measure of the pseudorandom properties of the system. Roughly, hereditary discrepancy measures how well one can $2$-color the elements of the system so that each set contains approximately the same number of elements of each color.
Greg Bodwin   +5 more
openaire   +6 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Vervet monkey (Chlorocebus pygerythrus) behavior in a multi-destination route: Evidence for planning ahead when heuristics fail. [PDF]

open access: yesPLoS ONE, 2018
Animal paths are analogous to intractable mathematical problems like the Traveling Salesman Problem (TSP) and the shortest path problem (SPP). Both the TSP and SPP require an individual to find the shortest path through multiple targets but the TSP ...
Julie Annette Teichroeb   +1 more
doaj   +1 more source

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