Results 61 to 70 of about 25,682 (291)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Interval shrinkage estimation of two-parameter exponential distribution with random censored data [PDF]
Journal of Mahani Mathematical ResearchThe use of the two-parameter exponential distribution model in fitting survival and reliability analysis data in the presence of censored random data has recently attracted the attention of a large number of authors.
Ali Soori +4 more
doaj +1 more source
Entropy, 2022 This study aims to propose modified semiparametric estimators based on six different penalty and shrinkage strategies for the estimation of a right-censored semiparametric regression model.
Syed Ejaz Ahmed +2 more
doaj +1 more source
Wavelet Estimators in Nonparametric Regression: A Comparative Simulation Study [PDF]
, 2001 Wavelet analysis has been found to be a powerful tool for the nonparametric estimation of spatially-variable objects. We discuss in detail wavelet methods in nonparametric regression, where the data are modelled as observations of a signal contaminated ...
Antoniadis, Anestis +2 more
core +7 more sources
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Bayesian Estimation Improves Prediction of Outcomes After Epilepsy Surgery
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We estimated the statistical power of studies predicting seizure freedom after epilepsy surgery. We extracted data from a Cochrane meta‐analysis. The median power across all studies was 14%. Studies with a median sample size or less (n ≤ 56) and a statistically significant result exaggerated the true effect size by a factor of 5.4, while the ...
Adam S. Dickey +4 more
wiley +1 more source
Appoximation-assisted [sic] estimation of eigenvectors under quadratic loss [PDF]
, 2005 Improved estimation of eigen vector of covariance matrix is considered under uncertain prior information (UPI) regarding the parameter vector. Like statistical models underlying the statistical inferences to be made, the prior information will be ...
Ahmed, S.E.
core
Optimal method in multiple regression with structural changes
, 2015 In this paper, we consider an estimation problem of the regression coefficients in multiple regression models with several unknown change-points. Under some realistic assumptions, we propose a class of estimators which includes as a special cases ...
Chen, Fuqi, Nkurunziza, Sévérien
core +1 more source
Nonlinear shrinkage estimation of large-dimensional covariance matrices [PDF]
, 2011 Many statistical applications require an estimate of a covariance matrix and/or its inverse. When the matrix dimension is large compared to the sample size, which happens frequently, the sample covariance matrix is known to perform poorly and may suffer ...
Ledoit, Olivier, Wolf, Michael
core +3 more sources
Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro +10 more
wiley +1 more source