Results 221 to 230 of about 4,290,946 (318)

Optimizing Donor Kidneys During Normothermic Machine Perfusion With Sevoflurane: Design of a Research Model

open access: yesArtificial Organs, EarlyView.
A stable kidney normothermic machine perfusion model with sevoflurane delivery via a vaporizer was established, enabling mechanistic and therapeutic studies of ischemia–reperfusion injury. ABSTRACT Normothermic machine perfusion (NMP) of donor kidneys provides an opportunity not only for organ preservation but also for therapeutic intervention to ...
Philip N. Günkel   +10 more
wiley   +1 more source

Alterations in Gut Microbiota and Metabolism in Cirrhotic Portal Hypertension: Implications for Disease Progression

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
In‐depth multiomics analyses revealed that the gut microbiota in patients with CPH is dysbiotic. Altered gut microbiota plays an important role in the progression of CPH and affects the host's arginine metabolism to promote arginine biosynthesis. The pro‐inflammatory effects of certain gut bacteria induce iNOS expression, which together act on the ...
Qun Zhang   +15 more
wiley   +1 more source

Transjugular intrahepatic portosystemic shunt with ePTFE-covered stentgrafts: incidence and predictors of shunt dysfunction. [PDF]

open access: yesInsights Imaging
Pitton MB   +8 more
europepmc   +1 more source

Biomarkers of Extracellular Matrix Remodelling Are Linked to Severity and Outcome of Advanced Chronic Liver Disease

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
Extracellular matrix (ECM) remodelling biomarkers reflect portal hypertension and disease severity in advanced chronic liver disease (ACLD). However, their predictive value for disease progression is largely restricted to compensated ACLD (cACLD). ABSTRACT Background Extracellular matrix (ECM) remodelling in advanced chronic liver disease (ACLD) is ...
Benedikt Simbrunner   +17 more
wiley   +1 more source

Indocyanine Green Clearance Correlates With Biomarkers Reflecting Key Disease‐Driving Mechanisms in Advanced Chronic Liver Disease and Predicts Acute‐on‐Chronic Liver Failure and Death

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
Indocyanine green clearance by pulse dye densitometry correlates with portal hypertension, systemic inflammation and circulatory dysfunction in advanced chronic liver disease. While diagnostic accuracy for CSPH was limited, ICG‐R15 independently predicted decompensation and ACLF/liver‐related mortality, highlighting its prognostic value across disease ...
Mathias Jachs   +17 more
wiley   +1 more source

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