Results 251 to 260 of about 4,290,946 (318)

Dasatinib Produces Lengthy Remissions of Extramedullary Leukemia: A Retrospective Observational Study

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Since 2004, patients receiving imatinib with relapse in non‐marrow sites were given dasatinib to preserve control of leukemic marrow. Remissions in CNS and other organs began to be reported and are continuously observed to present. With resistance to one BCR::ABL1 tyrosine kinase inhibitor and sensitivity to a dual BCR::ABL1/SRC inhibitor ...
I. Cunningham   +4 more
wiley   +1 more source

Cerebrospinal fluid pseudocyst presenting as ascites: A case report. [PDF]

open access: yesWorld J Hepatol
Quek SXZ   +4 more
europepmc   +1 more source

Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy

open access: yesEpilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim   +6 more
wiley   +1 more source

Equine botulism

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik   +2 more
wiley   +1 more source

Flow‐controlled expiration improves gas exchange in anaesthetised horses undergoing orthopaedic surgery

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Flow‐controlled expiration (FLEX) has been shown to significantly enhance oxygenation in horses under laboratory conditions. Objective This study aims to corroborate these findings by evaluating the effects of FLEX on gas exchange in a randomised clinical trial involving a large population of clinical horses undergoing orthopaedic ...
Klaus Hopster   +5 more
wiley   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

open access: yesThe FEBS Journal, EarlyView.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

E. coli and gut health—For the loser now will be later to win

open access: yesThe FEBS Journal, EarlyView.
In humans, commensal gut bacteria participate in a miniature nitrogen cycle, metabolizing dietary nitrate and nitrite. While these processes can generate harmful N‐nitrosamines, they may also produce beneficial nitric oxide (NO) or ammonium. Hager and colleagues demonstrate that E.
Jon O. Lundberg
wiley   +1 more source

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