The effect of friction in the hold down post spherical bearings on hold down post loads [PDF]
The effect of friction at the connection of the Solid Rocket Booster (SRB) aft skirt and the mobile launch platform (MLP) hold down posts was analyzed.
Richardson, James A.
core +1 more source
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
Encapsulating Metal-Organic-Framework Derived Nanocages into a Microcapsule for Shuttle Effect-Suppressive Lithium-Sulfur Batteries. [PDF]
Nanomaterials (Basel), 2022 Liu J +6 more
europepmc +1 more source
EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer
Advanced Science, EarlyView.This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv +8 more
wiley +1 more source
Recent progress in heterostructured materials for room‐temperature sodium‐sulfur batteries
Interdisciplinary MaterialsRoom‐temperature sodium‐sulfur (RT Na‐S) batteries are a promising next‐generation energy storage device due to their low cost, high energy density (1274 Wh kg−1), and environmental friendliness.
Haobin Song +7 more
doaj +1 more source
NiFe2O4/Ketjen Black Composites as Efficient Membrane Separators to Suppress the Shuttle Effect for Long-Life Lithium-Sulfur Batteries. [PDF]
Nanomaterials (Basel), 2022 Jiang W +7 more
europepmc +1 more source
Characterizing the uncertainty in holddown post load measurements [PDF]
In order to understand unexpectedly erratic load measurements in the launch-pad supports for the space shuttle, the sensitivities of the load cells in the supports were analyzed using simple probabilistic techniques.
Richardson, J. A., Townsend, J. S.
core +1 more source
Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development
Advanced Science, EarlyView.This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen +11 more
wiley +1 more source
Silica heat shield sizing [PDF]
The sensitivity of silica heat shield requirements to gap width, tile edge radius, and heat transfer distribution within tile gaps was investigated. A two-dimensional thermal model was modified and used to determine the effect of two dimensional heat ...
Christensen, H. E., Ebbesmeyer, L. H.
core +1 more source
Advanced Science, EarlyView.Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen +8 more
wiley +1 more source