Results 41 to 50 of about 16,195 (218)

Effect of Divided Exhaust Period in a High Efficiency TGDI Engine

Energies, 2021
The divided exhaust period (DEP) concept was applied to a high-efficiency gasoline engine and its impact on various engine performance aspects were investigated.
Heechang Oh, Dongwon Jung, Jinwook Son, Soohyung Woo, David Roth, Jerry Song, Youngmyung Kweon, Joonsik Hwang   +7 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating the influences of liquid LPG injection on spark ignition (SI) engine

MATEC Web of Conferences, 2017
Liquefied petroleum gas (LPG) is one of the alternative fuels that becoming popular to be use in spark ignition engine (SI). This paper briefly presents the influence of energy content to the engine output of 1.6L SI engine of Proton Gen 2.
Tukiman Mohd Mustaqim, Mustaffa Norrizal, Fawzi Mas, Osman Shahrul Azmir   +3 more
doaj   +1 more source

Frictional Losses of Ring Pack in SI and HCCI Engine

Energies, 2023
The vast majority of research dedicated to enhancing the homogenous charge compression ignition (HCCI) low-temperature combustion system is focused on improving controllability, efficiency and emissions.
Grzegorz Koszalka, Andrzej Wolff
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Development of a spark discharge model for predicting ignition stability in high EGR conditions in SI engines

Nihon Kikai Gakkai ronbunshu
Recently, EGR (Exhaust Gas Recirculation) combustion has been used to enhance the thermal efficiency of internal combustion engines. However, EGR combustion causes ignition instability, leading to increased cycle-to-cycle combustion variability and ...
Ryo ADACHI, Kunihiko SUGANUMA, Kenji KOIWA, Shinji NAKAYA, Fangsi REN   +4 more
doaj   +1 more source