Results 81 to 90 of about 15,498 (265)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The mechanism and effect factors of the combustion cycle‐to‐cycle variations in the spark ignition engine

Energy Science & Engineering
The combustion cycle‐to‐cycle variations (CCV) are the typical combustion phenomena in the internal combustion engine, which will not only affect the combustion efficiency, heat‐work conversion process, and emission formation in the cylinder, but also ...
Xiongbo Duan, Lining Feng, Yan Xia
doaj   +1 more source

1D model and rule-based calibration strategy to improve the performance of a turbocharged spark ignition engine over the whole engine map

Engineering Science and Technology, an International Journal
This paper deals with the performance improvement of a turbocharged spark ignition (SI) engine redesigned by adopting a refined 1D model and a rule-based (RB) calibration strategy.
Dino Pirrello, Luigi Teodosio, Fabio Berni   +2 more
doaj   +1 more source

Performance and emissions of SI engine with additives

Journal of Physics: Conference Series, 2019
Abstract In the current economy with rising fuel prices and higher concerns being raised for the safety of the environment, it creates an opportunity to test additives available in the market to achieve lower emissions with an increase in performance.
Sai Vijay Venkatesh, R Udayakumar
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

HYDROGEN ADDITION ON COMBUSTION AND EMISSION CHARACTERISTICS OF HIGH SPEED SPARK IGNITION ENGINE- AN EXPERIMENTAL STUDY [PDF]

Journal of Engineering Science and Technology, 2016
The present article aims at characterizing the combustion and emission parameters of a single cylinder high speed SI engine operating with different concentrations of hydrogen with gasoline fuel.
SHIVAPRASAD K. V. , P. R. CHITRAGAR, KUMAR G. N.   +2 more
doaj  

Response surface methodology application on lubricant oil degradation, performance, and emissions in SI engine: A novel optimization of alcoholic fuel blends. [PDF]

Sci Prog, 2023
Ijaz Malik MA, Usman M, Akhtar M, Farooq M, Farooq M, Saleem Iqbal HM, Irshad M, Shah MH.   +7 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Cycle-skipping strategy with intake air cut off for natural gas fueled Si engine. [PDF]

Sci Prog, 2021
Tunçer E, Sandalci T, Pusat S, Balcı Ö, Karagöz Y.   +4 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source