Results 41 to 50 of about 5,671 (220)

SIADH Associated with Prostate Cancer [PDF]

Electrolyte & Blood Pressure, 2007
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common disease leading to hyponatremia, and it is characterized by an inappropriately elevated serum ADH level relative to serum osmolality. This syndrome may occur in a variety of clinical settings including malignancies.
Lee, Kyun Sang, Kang, Taek Won, Ma, Seong Kwon, Kim, Soo Wan, Kim, Nam Ho, Choi, Ki Chul   +5 more
openaire   +2 more sources

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1522-1536, June 2026.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

Efficacy of MAPK inhibitors in children with neurodegenerative Langerhans cell histiocytosis: Results from the European Consortium for Histiocytosis

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Neurodegenerative Langerhans cell histiocytosis (ND‐LCH) is a severe and debilitating complication of LCH with no effective treatment. In this study, we assessed the efficacy of MAPK inhibitors (MAPKi) in a large cohort of children with ND‐LCH. We included pediatric patients with ND‐LCH who received MAPKi between 2013 and 2025.
Francesco Pegoraro, Francois Chalard, Dmitry Evseev, Mohamed Barkaoui, Solenne Le Louet, Julian Thalhammer, Nathalie Aladjidi, Alexandra Salmon, Perrine Marec‐Berard, Stefania Gaspari, Carmela De Fusco, Irene Trambusti, Antonio Verrico, Anna Raciborska, Karel Svojgr, Zdenka Křenová, Olga Slater, Gerard Millen, Myriam Ben Arush, Dana Ashkenazi Lustig, Tatiana Von Bahr Greenwood, Caroline Hutter, Itziar Astigarraga, Mónica López‐Duarte, Lorena Valero‐Arrese, María José Ortega Acosta, Cor van den Bos, Leonie Naeije, Daniel Martin‐Munoz, Anna Perrone, Marzia Mortilla, Olivier Felician, Ahmed Idbaih, Sébastien Héritier, Vasanta Nanduri, Milen Minkov, Jan‐Inge Henter, Elena Sieni, Jean Donadieu   +38 more
wiley   +1 more source

Three Synchronous Tumors Discovered in SIADH Investigation [PDF]

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is a common cause of euvolemic hyponatremia which has many possible etiologies such as tumors (mainly lung cancers). We present a case of a 79-year old women hospitalized due to microcytic
Fonseca, Ricardo, Monteiro, Filipa
core   +1 more source

Case Report: Long-Term Tolvaptan Treatment in a Child With SIADH and Suprasellar Arachnoid Cyst

Frontiers in Pediatrics, 2021
Suprasellar arachnoid cysts represent a rare occurrence in the pediatric population and usually cause symptoms related to mass effect and can occasionally cause endocrine dysfunctions.
Andrea Puma, Milena Brugnara, Paolo Cavarzere, Marco Zaffanello, Giorgio Piacentini, Rossella Gaudino   +5 more
doaj   +1 more source

Recovery From SIADH-Associated Osteoporosis:A Case Report

, 2014
INTRODUCTION: Recent studies show an association between hyponatremia and osteoporosis. We have previously reported a case of severe male osteoporosis due to chronic syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
Eiken, Pia, Sejling, A. S., Eiken, P., Pedersen-Bjergaard, U., Sejling, Anne-Sophie, Thorsteinsson, Anne-Luise, Thorsteinsson, A. L., Pedersen-Bjergaard, Ulrik   +7 more
core   +1 more source

Efficacy and safety of long-term tolvaptan treatment in a patient with SCLC and SIADH

, 2015
Hyponatremia frequently occurs in patients with cancer and is mostly due to a syndrome of inappropriate antidiuresis caused by ectopic secretion of antidiuretic hormone (SIADH). Small cell lung cancer presents with SIADH in approximately 11%-15% of cases.
Regolisti G., Buti S., Tiseo M., Ardizzoni A., Bordi P.   +4 more
core   +2 more sources

An Atypical Presentation of Tuberculous Ascites, Severe Hyponatremia, and Acute Kidney Injury in a Young Male

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT A 25‐year‐old male who had been in good health before presenting with right lower lobe pneumonia, severe hyponatremia (Na 117 mEq/L), distension, and reduced urine output. AKI secondary to acute glomerulonephritis (GN) or interstitial nephritis was suggested by the initial workup. He was discharged for outpatient nephrology follow‐up following
Bassem Al Hariri, Muhammad Sharif, Memon Noor Illahi, Asgad Mohamed Ahmed Eltigani, Usamah Saad Mohammad Al Anbagi, Muayad Ahmad   +5 more
wiley   +1 more source

Acute Intermittent Porphyria Triggered by COVID‐19 Mimicking Guillain–Barré Syndrome: A Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Acute intermittent porphyria (AIP) is a rare heme biosynthesis disorder in which the accumulation of neurotoxic porphyrin precursors precipitates neurovisceral attacks. Intercurrent infections, including coronavirus disease 2019 (COVID‐19), may trigger or exacerbate AIP and complicate diagnosis, as clinical manifestations can resemble those of
Payman Sadeghi, Masood Ghahvechi Akbari, Seyed Abbas Hassani, Hosein Alimadadi, Morteza Heidari, Vahid Ziaee   +5 more
wiley   +1 more source

The Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)

, 2009
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a disorder of water balance characterized by hypotonic hyponatremia and impaired water excretion.
Decaux, Guy
core   +1 more source