Results 141 to 150 of about 2,579,458 (259)
REMODELLING OF GLYCOPROTEINS WITH SIALIC ACID ANALOGUES [PDF]
To complete their biosynthesis many soluble or membrane bound glycoconjugates require a final sialylation step which is catalyzed by distinct sialyltransferases differing in specificity with respect to the glycan acceptor structure and the linkage ...
Groß, H. J. +7 more
core +1 more source
ChemBioChem, Volume 27, Issue 19, 14 October 2026.Gut microbiota associated with pediatric autism spectrum disorder exhibit functional heterogeneity characterized by altered fecal lipopolysaccharide landscapes, metabolic remodeling, and enhanced microglial inflammatory responses despite largely preserved microbial composition.
Stefania De Chiara +10 more
wiley +1 more source
Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano +3 more
wiley +1 more source
Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2605-2612, October 2026.ABSTRACT Alpha‐1‐antitrypsin (A1AT) is a multifunctional, clinically important, high‐value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes, graft‐versus‐host disease, cystic fibrosis, and various viral infections. Currently, the only U.S. food and drug administration‐approved treatment for
Frances Rocamora +12 more
wiley +1 more source
Intracellular Delivery of Hydrophilic Glycans Using Superchaotropic Clusters
Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.Superchaotropic boron clusters are demonstrated to deliver hydrophilic glycans directly into mammalian cells, removing the need for acetylation and cytotoxic solvents such as DMSO. Azido glycans for metabolic oligosaccharide engineering, and trehalose, were delivered and the successful azido‐labelling of glycoproteins, cell surface glycans, and ...
Qiao Tang +2 more
wiley +2 more sources
The Biosynthesis of Sialic Acids
Journal of Biological Chemistry, 1962 L, WARREN, H, FELSENFELD
openaire +2 more sources
International Journal of Gynecology &Obstetrics, Volume 175, Issue 1, Page 453-465, October 2026.Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao +5 more
wiley +1 more source