Results 221 to 230 of about 5,135,061 (391)

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2016
M. Perdicchio   +17 more
semanticscholar   +1 more source

Group A Streptococcus interacts with glycosaminoglycans via M proteins to modulate bacterial adherence in vitro

open access: yesThe FEBS Journal, EarlyView.
Interactions between bacteria and the extracellular matrix are a prerequisite for colonisation and infection. Phylogenetically diverse M proteins of group A Streptococcus (GAS) can selectively bind sulfated glycosaminoglycans with high affinity. M protein‐mediated recruitment of chondroitin sulfate and dermatan sulfate was shown to increase GAS ...
Tahnee B.‐D. McEwan   +8 more
wiley   +1 more source

Sialic acid deficiency is associated with oxidative stress leading to muscle atrophy and weakness in GNE myopathy

open access: yesHuman Molecular Genetics, 2017
A. Cho   +6 more
semanticscholar   +1 more source

Impact of N‐linked glycans on the dual short fibulin/LTBP‐4 axes regulating elastogenesis

open access: yesThe FEBS Journal, EarlyView.
Elastic fiber assembly is orchestrated by multiple glycoproteins. We delineate the molecular basis of two key axes involved in elastic fiber formation—LTBP‐4L/fibulin‐4 and LTBP‐4S/fibulin‐5. We show that N‐linked glycans on these glycoproteins regulate their interactions and conformations, both of which are critical aspects in elastic fiber formation.
Valentin Nelea   +8 more
wiley   +1 more source

Blood group O expression in normal tissues and tumors

open access: yesThe FEBS Journal, EarlyView.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin   +11 more
wiley   +1 more source

Steering Siglec-Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry.

open access: yesAngewandte Chemie, 2017
C. Büll   +10 more
semanticscholar   +1 more source

Enhancing macrophage phagocytosis of cancers by disrupting the SIRPα/CD47 signaling axis and targeting MUC1 antigen

open access: yesThe FEBS Journal, EarlyView.
We investigated the role of the signal regulatory protein alpha (SIRPα)/CD47 axis in phagocytosis by disrupting the SIRPA gene in the THP‐1 cell line. The SIRPα KO THP‐1 cells retained their monocyte and macrophage characteristics similar to their wild‐type (WT) counterparts.
Saitong Muneekaew   +5 more
wiley   +1 more source

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