Results 251 to 260 of about 113,461 (351)

A Surface Plasmon Resonance‐Based Integrated Assay for Quantification and Glycosylation Characterization of Monoclonal Antibodies in Crude Heterogeneous Samples

Biotechnology and Bioengineering, Volume 122, Issue 10, Page 2724-2738, October 2025.
ABSTRACT The rise in cancer, autoimmune, inflammatory, and infectious diseases in recent decades has led to a surge in the development of monoclonal antibodies (mAbs) therapies, now the most widely used family of biologics. To meet the growing global demand, biopharmaceutical industries are intensifying their production processes.
Ilona Metayer, Catherine Forest‐Nault, Julie Guimond, Simon Joubert, Olivier Henry, Yves Durocher, Gregory De Crescenzo, Jimmy Gaudreault   +7 more
wiley   +1 more source

Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors. [PDF]

Eng Life Sci
Chemmalil L, Kulkarni T, Raman M, Singh P, Qian Y, Chumsae C, McHugh K, Huang Z, Hodgman E, Borys MC, Ding J, Li G, Leone A.   +12 more
europepmc   +1 more source

Peptide Modulation Overrides Glycan Synergy in Gold Nanoparticle‐Based Vaccines for Cancer Immunotherapy

Cancer Medicine, Volume 14, Issue 19, October 2025.
This study explores how antigen peptides and sugar chains affect the efficacy of glyco‐nanovaccines (iGN) in cancer immunotherapy. We show that antigen peptides, rather than sugar chains, are key to nanoparticle uptake and immune activation, with sialic acid‐modified iGN showing similar anti‐cancer efficacy to α‐mannose‐modified iGN in a mouse model ...
Narumi Harada, Mayumi Niimura, Yasuhisa Sakamoto, Akihiro Nita, Mayuko Shimoda, Shiho Wada, Koki Murata, Masahiro Wakao, Tomomi Kamba, Hiroyuki Shinchi, Toshiro Moroishi   +10 more
wiley   +1 more source

Profiling the regulatory landscape of sialylation through miRNA targeting of CMP- sialic acid synthetase. [PDF]

J Biol Chem
Jame-Chenarboo F, Reyes JN, Arachchige TU, Mahal LK.   +3 more
europepmc   +1 more source

The studies on sialic acid of platelets

, 1977
Koneo YAMADA, Akira Shinkai, Akira Shirahata, Takashi Meguro   +3 more
openalex   +2 more sources

Estrogen Modulation of B Cell Immunity: Implications for HIV Control and Therapeutic Strategies

Comprehensive Physiology, Volume 15, Issue 5, October 2025.
Estrogen significantly modulates B‐cell immunity. We provide evidence for estrogen–B‐cell crosstalk (the estrogen–B‐cell axis) in regulating B‐cell function and shaping HIV acquisition, progression, and persistence, and highlight research gaps to guide hormone‐aware vaccines and therapies.
John Kasibante, Todd T. Brown, Jordan E. Lake, Mohamed Abdel‐Mohsen   +3 more
wiley   +1 more source

RETRACTION: Synthesis and Cardiovascular Protective Effects of Quercetin 7-O-Sialic Acid. [PDF]

J Cell Mol Med
europepmc   +1 more source

Dysbiosis-associated gut bacterium <i>Ruminococcus gnavus</i> varies at the strain level in its ability to utilize key mucin component sialic acid. [PDF]

Microbiol Spectr
Sokolovskaya OM, Uzunovic J, Peng Y, Okumura M, Wang LM, Zhou Y, Lai Z, Skippington E, Tan M-W.   +8 more
europepmc   +1 more source

Isolation of wheat germ agglutinin-resistant clones of Chinese hamster ovary cells deficient in membrane sialic acid and galactose.

, 1977
Eve Barak Briles, E. Li, Stuart Kornfeld
openalex   +1 more source

Characterization of Proteomic Pharmacodynamic Biomarkers of IFNβ‐1a Biologics to Inform Potential Utility in Biosimilar Development

Clinical Pharmacology &Therapeutics, Volume 118, Issue 4, Page 935-945, October 2025.
Pharmacodynamic (PD) biomarkers can support biosimilarity assessment, potentially reducing the need for comparative clinical efficacy studies. This study aimed to characterize previously identified proteomic PD biomarker candidates for Interferon beta‐1a (IFNβ‐1a, n = 248) and pegylated IFNβ‐1a (pegIFNβ‐1a, n = 528) biologics at therapeutic doses, to ...
Lakshmi Manasa S. Chekka, Deepti P. Samarth, Yan Guo, Esraa G. Mohamed, Erica Decker, Murali K. Matta, Qin Sun, William Wheeler, Carlos Sanabria, Joel Wommack, Joseph Gogain, Sarah J. Schrieber, Jeffry Florian, Yow‐Ming Wang, David G. Strauss, Paula L. Hyland   +15 more
wiley   +1 more source