Results 91 to 100 of about 17,851 (232)
A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation
Clinical Pharmacology &Therapeutics, EarlyView.The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix +4 more
wiley +1 more source
Discover Social Science and HealthA house is more than just a physical structure; its conditions have a significant impact on our physical and mental health as well as our general quality of life. Housing issues and sick building syndrome have complex dynamics.
Olaitan Olutayo Odunola +4 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
Salāmat-i kār-i Īrān, 2011 Background and aims Building associated illnesses are a group of illnesses caused by physical or psychological conditions of workplace. One of theses illnesses is sick building syndrome (SBS) which consists of a group of symptoms, including mucosal ...
F. Nourani Yazdi +5 more
doaj
Clinical and Experimental Dental Research, EarlyView.Abstract Background Family plays a significant role in children's dental and oral health (DOH) elements, such as children's DOH knowledge and practice, the development of children's dental fear and anxiety (DFA), children's dental visits, and children's DOH status.
Wisnu Fadila +5 more
wiley +1 more source
A Meta‐Analysis and Systematic Review of Single‐Session Interventions for Eating Disorders
International Journal of Eating Disorders, EarlyView.ABSTRACT Background There is a critical gap between the need for eating disorder (ED) treatment and provider availability. Single‐Session Interventions (SSIs) are structured programs intentionally designed for a single client encounter and show promise for filling ED‐treatment and prevention gaps by enhancing accessibility of evidence‐based ...
Sonakshi Negi +3 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective The efficacy of psychological therapies for adolescents and adults with avoidant/restrictive food intake disorder (ARFID) has yet to be rigorously analyzed through systematic review or meta‐analysis. Method We identified articles from seven databases that presented psychological therapies for adolescents and adults with ARFID. First,
Copeland G. Winten +4 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi +6 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective This cohort study examined the agreement between youth‐ and parent‐reported health‐related quality of life (HRQOL) of children treated with epilepsy surgery compared to medical therapy. A second aim was to evaluate whether changes in HRQOL over 2 years differed between the two groups, and to determine whether these trajectories ...
Mary Lou Smith +2 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis (NDEEMA) represents the most severe end of the gain‐of‐function (GOF) SCN1A disorder spectrum. Sporadic cases of congenital arthrogryposis have also been reported in individuals with SCN2A‐, SCN3A‐, and SCN8A‐related developmental and ...
Sopio Gverdtsiteli +43 more
wiley +1 more source