Results 191 to 200 of about 684,037 (352)

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

open access: yesAdvanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang   +15 more
wiley   +1 more source

Reliable AI Platform for Monitoring BCI Caused Brain Injury and Providing Real‐Time Protection

open access: yesAdvanced Science, EarlyView.
BrainGuard enables real‐time and interpretable assessment of brain injury caused by brain computer interface (BCI). Using feature‐based Gaussian process (GP) emulators trained on limited biomechanical data, it efficiently predicts full‐field strain and constructs patient‐specific digital brain twins to support clinical diagnosis and long‐term BCI ...
Chufan He   +3 more
wiley   +1 more source

Associations between workplace aggression and subsequent mental distress and sick leave among home care workers. [PDF]

open access: yesInt Arch Occup Environ Health
Knutsen RH   +3 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

open access: yesAdvanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li   +17 more
wiley   +1 more source

Sick Leave and the Composition of Work Teams [PDF]

open access: yes
In this paper, I analyse the relation between workers’ sick leave and the composition of their work teams with respect to age, job tenure, education, and nationality.
Matthias Weiss
core  

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

open access: yesAdvanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen   +16 more
wiley   +1 more source

Home - About - Disclaimer - Privacy