Results 211 to 220 of about 684,037 (352)

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Post-Covid-19 symptoms, subjective work ability and sick leave 2 years after acute infection-results from a population-based long COVID study. [PDF]

BMC Public Health
Braig S, Peter RS, Nieters A, Kräusslich HG, Brockmann SO, Göpel S, Merle U, Steinacker JM, Kern WV, Rothenbacher D, EPILOC Phase 3a Study Group.   +10 more
europepmc   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Sick leave before and after a work-place targeted terror attack [PDF]

, 2018
Marianne Bang Hansen, Mona Berthelsen, Alexander Nissen, Trond Heir   +3 more
openalex   +1 more source

Explicit Compression Degradation Estimations for Low‐Sampling Single‐Pixel Imaging using Hadamard Basis

Advanced Science, EarlyView.
This study proposes a degradation estimation technique to explicitly describe compressive sampling for low‐sampling Hadamard single‐pixel imaging. Blur kernels in explicit degradation models are estimated by the self‐supervised learning method without labeled data and implicit priors.
Haoyu Zhang, Jie Cao, Chang Zhou, Haifeng Yao, Qun Hao   +4 more
wiley   +1 more source

Work ability trajectories and sick leave in individuals with post COVID-19 condition: 3-year follow-up of a population-based cohort. [PDF]

Lancet Reg Health Eur
Ballouz T, Kerksieck P, Haile SR, Dressel H, Hämmig O, Bauer GF, Fehr JS, Puhan MA, Menges D.   +8 more
europepmc   +1 more source

Association between Sick Leave Prescribing Practices and Physician Burnout and Empathy

, 2015
Oriol Yuguero Torres, Montse Esquerda, Josep Ramón Marsal, Jorge Soler-González   +3 more
openalex   +2 more sources

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Relationship between duration of sick leave and time variation of words used in return-to-work programs for depression

, 2023
Ichiro Kutsuna, Aiko Hoshino, Ami Morisugi, Yukari Mori, Aki Shirato, Mirai Takeda, Hikari isaji, Mami Suwa   +7 more
openalex   +2 more sources

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source