Results 191 to 200 of about 84,336 (257)

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Patterns of sick leave and unemployment prior to a diagnosis of young onset Alzheimer's disease. [PDF]

Alzheimers Dement
Damsgaard L, Pedersen J, Laursen TM, Nabe-Nielsen K, Hendriks S, Jensen-Dahm C, Waldemar G, Janbek J.   +7 more
europepmc   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Non-standard employment, paid sick leave, and income loss during COVID-19 self-isolation: cross-sectional findings from South Korea. [PDF]

Int J Equity Health
Hwang S.
europepmc   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Predictors of sustained return to work after sick leave due to mental disorders. [PDF]

Rev Bras Med Trab
Muntanelli BR, Silva-Junior JS.
europepmc   +1 more source

Non‐Hermitian Stealthy Hyperuniformity

Advanced Science, EarlyView.
A framework for non‐Hermitian extensions of hyperuniformity and stealthiness is proposed, generalizing PT‐symmetric gain‐loss crystals to correlated disorder in the weak‐scattering limit. By engineering real‐imaginary correlations of the material potential, this framework enables directional scattering phases inaccessible in Hermitian materials ...
Gitae Lee, Seungmok Youn, Ikbeom Lee, Kunwoo Park, Duhwan Hwang, Seungkyun Park, Xianji Piao, Namkyoo Park, Sunkyu Yu   +8 more
wiley   +1 more source

Flex-ability - A key concept to promote occupational health in everyday life beyond sick leave. [PDF]

Work
Karlsson L, Erlandsson LK, Cregård A, Nordgren L, Lydell M.   +4 more
europepmc   +1 more source

Psychosocial well-being index and sick leave in the workplace: a structural equation modeling of Wittyfit data. [PDF]

Front Psychol
Colin-Chevalier R, Pereira B, Dewavrin S, Cornet T, Baker JS, Dutheil F.   +5 more
europepmc   +1 more source

[Physicians and sick leave].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2007
openaire   +1 more source