Results 191 to 200 of about 22,367,796 (324)

Perceptions of cancer survivors and healthcare professionals on adequate supportive care after treatment of cancer: An in-depth qualitative study. [PDF]

PLoS One
van der Smissen D, Lugtenberg M, Abdeselam Rocdi Y, Beerepoot LV, Mols F, Brouwers EPM, Wasowicz DK, Joosen MCW.   +7 more
europepmc   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Critical exposure: the role of medical school intensive care unit rotations. [PDF]

ATS Sch
Rose EV, Gergen DJ, Neumeier AT.
europepmc   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

A Web-Based Self-Management Intervention for Return-to-Work Among Persons With Common Mental Disorders on Sick Leave: Case Study of mWorks. [PDF]

JMIR Form Res
Engdahl P, Svedberg P, Bejerholm U.
europepmc   +1 more source

Sick Leave for Bill

Sick leave to a bill to be ...

core  

CoSP: Reconfigurable Metamaterial Inverse Design via Contrastive Pretrained Large Language Model

Advanced Science, EarlyView.
In this work, CoSP (contrastive multi‐state pretrain), an intelligent inverse design method for reconfigurable metamaterials based on a contrastive pretrained large language model, is proposed. Numerical experiments demonstrate that CoSP can design reconfigurable metamaterial structures for multi‐state, multi‐band optical responses, showing great ...
Shujie Yang, Yuqi Zhang, Xuzhe Zhao, Yansong Tang, Kaichen Dong   +4 more
wiley   +1 more source

Exploring workplace conflicts: a qualitative study on the needs and challenges of employees, employers, and occupational health professionals. [PDF]

BMC Public Health
Hoeve ST, de Wind A, Anema JR, Juurlink T.   +3 more
europepmc   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Logic, inference, understanding: cross-domain generalization for generative language models. [PDF]

Front Artif Intell
Blanck R, Noble B.
europepmc   +1 more source