Results 111 to 120 of about 46,933 (301)

A Functional Assay for Sick Sinus Syndrome Genetic Variants

Cellular Physiology and Biochemistry, 2017
Background/Aims: Congenital Sick Sinus Syndrome (SSS) is a disorder associated with sudden cardiac death due to severe bradycardia and prolonged pauses.
C. Jou, Cammon B. Arrington, Spencer M. Barnett, Jiaxiang Shen, Scott Cho, X. Sheng, Patrick C. McCullagh, N. Bowles, Chase M. Pribble, E. Saarel, T. Pilcher, S. Etheridge, M. Tristani-Firouzi   +12 more
semanticscholar   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

, 2011
Contains fulltext : 95597.pdf (Publisher’s version ) (Open Access)Through complementary application of SNP genotyping, whole-genome sequencing and imputation in 38,384 Icelanders, we have discovered a previously unidentified sick sinus ...
Masson, Gisli, Arnar, David O, Thorleifsson, Gudmar, Hilma Holm, Agnar Helgason, Gudbjartsson, D.F., Helgadottir, H.T., Hreinn Stefansson, Masson, G., Sulem, P., Lambertus A Kiemeney, Kiemeney, L.A.L.M., Matthiasson, S.E., Gylfason, A, Walters, G Bragi, Rafnar, Thorunn, Augustine Kong, Walters, G.B., Gudmar Thorleifsson, Muhammad, Raafia, Olafur Th Magnusson, Stefansson, Kari, Thomas Werge, Parvez, Babar, David O Arnar, Darbar, Dawood, Asgeir Sigurdsson, Muhammad, R., Gylfason, Arnaldur, Solveig Gretarsdottir, Arnaldur Gylfason, Sigurdsson, Asgeir, Arnar, D.O., Matthiasson, Stefan E, Gretarsdottir, Solveig, Raafia Muhammad, Zanon, C., Jonasdottir, A., Magnusson, Olafur Th, Roden, Dan M, G Bragi Walters, Parvez, B., Stefan E Matthiasson, Stefansdottir, H., Thorgeirsson, G.M., Thorgeirsson, Gudmundur, Holm, H., Carlo Zanon, Babar Parvez, Thorsteinsdottir, Unnur, Patrick Sulem, Hrafnhildur Stefansdottir, Stefansdottir, Hrafnhildur, Gretarsdottir, S., Daniel F Gudbjartsson, Dawood Darbar, Gudbjartsson, Daniel F, Thorsteinsdottir, U., Helgadottir, Hafdis Th, Stefansson, K., Holm, Hilma, Thorunn Rafnar, Kong, Augustine, Thorgeirsson, Gu Mundur, Sigurdsson, A., Magnusson, O.T., Darbar, D., Saemundsdottir, J., Gisli Masson, Helgason, Agnar, Aslaug Jonasdottir, Sulem, Patrick, Helgason, A., Rafnar, T., Kari Stefansson, Stefansson, H., Saemundsdottir, Jona, Jonasdottir, Aslaug, Hafdis Th Helgadottir, Thorleifsson, G., Werge, T., Stefansson, Hreinn, Werge, Thomas, Kiemeney, Lambertus A, Jona Saemundsdottir, Gu∂mundur Thorgeirsson, Dan M Roden, Kong, A., Zanon, Carlo, Unnur Thorsteinsdottir, Roden, D.M.   +90 more
core   +1 more source

Asthma and Multimorbidity Amongst Ethnic Minority Groups in High Income Countries

Clinical &Experimental Allergy, EarlyView.
There is a tight intersection between asthma, deprivation, ethnicity, multimorbidity and poor clinical outcomes. An integrated, holistic and culturally tailored approach is needed to improve clinical outcomes amongst ethnic minority groups with asthma and multimorbidity. ABSTRACT Asthma is one of the commonest noncommunicable diseases worldwide.
Mamidipudi Thirumala Krishna, Saibal Moitra, Anna Freeman, Ben Ainsworth, Rebecca Knibb, Ramesh Kurukulaaratchy, Adel H. Mansur   +6 more
wiley   +1 more source

Frailty and Fitness in Older Adults With Acute Myeloid Leukemia: From Chronological Age to Multiparametric Assessment

European Journal of Haematology, EarlyView.
ABSTRACT Acute Myeloid Leukemia predominantly affects older adults, who often present with comorbidities, functional impairment, and frailty, limiting eligibility for intensive chemotherapy or allogeneic transplantation. Historically, treatment options were restricted to hypomethylating agents, low‐dose cytarabine, hydroxyurea, or supportive care, with
Antonella Bruzzese, Enrica Antonia Martino, Santino Caserta, Maria Eugenia Alvaro, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Ernesto Vigna, Massimo Gentile   +11 more
wiley   +1 more source

Sinus automaticity and sinoatrial conduction in severe symptomatic sick sinus syndrome

, 1992
Electrophysiologic studies with recordings of sinus node electrograms were performed in 38 patients with severe symptomatic sick sinus syndrome. Thirty-two of the 38 patients had episodic tachyarrhythmias and 17 presented with syncope.
Lin, Fun-Chung, Yeh, San-Jou, Cherng, Wen-Jin, Wu, Delon, Wang, Chun-Chieh   +4 more
core   +1 more source

Mitral regurgitation and decompensated heart failure in a young pregnant pony mare: An aetiological challenge

Equine Veterinary Education, EarlyView.
Summary A 4‐year‐old, 6‐month pregnant, Welsh pony mare presented with severe acute clinical signs including depression, anorexia, pale mucous membranes, tachycardia with a grade 4/6 holosystolic murmur and moderate expiratory dyspnoea with diffuse wheezes. There was no evidence of placentitis or fetal distress.
M. F. David, L. Cannon, A. Tortereau, A. Thomas‐Cancian, I. Desjardins   +4 more
wiley   +1 more source

Sick sinus node syndrome. ¿Diagnostic doubts... therapeutic doubts...?

Acta Médica del Centro, 2008
The sick sinus node syndrome is the causing factor of aproximately half of permanent pacemaker implants in the United States and Europe, and the first cause of its use in people under 40 years of age; however, since the end of the 60s when the term sick ...
Ginner O. Rizo Rivera, Raimundo Carmona Puerta, Gustavo Padrón Peña   +2 more
doaj  

Noncontact Mapping-Guided Catheter Ablation of Posterosuperior Right Atrial Tachycardia Associated with Sick Sinus Syndrome

Journal of Arrhythmia, 2008
Focal atrial tachycardia (AT) is sometimes associated with sick sinus syndrome. A 57-year-old female complained of palpitation, fatigue and presyncope. Ambulatory monitoring demonstrated frequent segments of AT and subsequent sinus arrests.
Shioto Yasuda, MD, Hirofumi Nakamura, MD, Eiji Karashima, MD, Jin Ueda, MD, Gen Nakaji, MD, Hideki Shimazu, MD, Shin-ichi Hiramatsu, MD, Keita Odashiro, MD, Toru Maruyama, MD, Yoshikazu Kaji, MD   +9 more
doaj   +1 more source

Effect of amiodarone on sinus node function in patients with sick sinus syndrome

, 1987
The effect of amiodarone on sinus node function has been studied in 9 patients with symptomatic sick sinus node as documented by Holter-ECG. All patients had programmable dual-chamber pacemakers.
M. Jost, Jost, M., Burckhardt, D., L. Kappenberger, A. Hoffmann, D. Burckhardt, Hoffmann, A., Kappenberger, L.   +7 more
core   +1 more source