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Clinics in Perinatology, 2001
The initiation of newborn screening and its virtually universal implementation will eventually yield a population in which sickle cell disease has been identified and comprehensive care is provided for children. The situation with SCT is different; there will continue to be the identification of parents who have the potential for having a child with a ...
C F, Whitten, W, Whitten-Shurney
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The initiation of newborn screening and its virtually universal implementation will eventually yield a population in which sickle cell disease has been identified and comprehensive care is provided for children. The situation with SCT is different; there will continue to be the identification of parents who have the potential for having a child with a ...
C F, Whitten, W, Whitten-Shurney
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Sickle-cell trait and sickle-cell anaemia
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1951Abstract (1) If sickle-cell trait is regarded as a heterozygous condition (Ss) and sickle-cell anaemia as a homozygous state (SS), then sickle-cell anaemia can only arise as a result of the mating of two heterozygous individuals (Ss x Ss), or the mating of a heterozygous and a homozygous (Ss x SS) or of two homozygous (SS x SS). 1.
H, FOY, A, KONDI, C, ALEXANDRIDES
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Hemophagocytosis of Sickle Cells
New England Journal of Medicine, 2020Hemophagocytosis of Sickle Cells A 60-year-old man with sickle cell disease presented with fatigue and shortness of breath.
Felix, Mensah, Monica, Pilichowska
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The Rate of Sickling of Cells Containing Sickle-Cell Haemoglobin
Clinical Science, 19731. A rapid-reaction apparatus was used to measure the rate at which cells containing sickle-cell haemoglobin (HbS) undergo morphological changes as a result of very rapid deoxygenation. The events occurring under these circumstances were found to take place in two stages. 2.
M W, Rampling, J A, Sirs
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Annals of Internal Medicine, 2021
Sickle cell disease is an umbrella term for a group of hemoglobinopathies characterized by the presence of 2 β-globin gene mutations or deletions, at least 1 of which is the point mutation that leads to the production of hemoglobin S. Sickle cell disease is associated with hemolytic anemia, significant chronic end-organ damage, and early death. In high-
Lydia H, Pecker, Sophie, Lanzkron
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Sickle cell disease is an umbrella term for a group of hemoglobinopathies characterized by the presence of 2 β-globin gene mutations or deletions, at least 1 of which is the point mutation that leads to the production of hemoglobin S. Sickle cell disease is associated with hemolytic anemia, significant chronic end-organ damage, and early death. In high-
Lydia H, Pecker, Sophie, Lanzkron
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Journal of Pediatric Hematology/Oncology, 1993
We have developed and applied simple techniques for the detection of irreversibly and reversibly sickled cells (ISCs and RSCs) in blood samples. Both ISCs and RSCs are found in the venous and arterial circulation, and sickling and unsickling occurs continuously in the tissues and arterial blood, respectively.Using these techniques, we have studied the ...
A, Zipursky, D M, Chachula, E J, Brown
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We have developed and applied simple techniques for the detection of irreversibly and reversibly sickled cells (ISCs and RSCs) in blood samples. Both ISCs and RSCs are found in the venous and arterial circulation, and sickling and unsickling occurs continuously in the tissues and arterial blood, respectively.Using these techniques, we have studied the ...
A, Zipursky, D M, Chachula, E J, Brown
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Annals of Internal Medicine, 1970
Excerpt Patients with sickle-cell anemia have a defect in renal concentrating ability. This abnormality has been characterized functionally as an inability to attain normal maximum osmolality level...
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Excerpt Patients with sickle-cell anemia have a defect in renal concentrating ability. This abnormality has been characterized functionally as an inability to attain normal maximum osmolality level...
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Irreversibly Sickled Cells and Splenomegaly in Sickle‐Cell Anaemia
British Journal of Haematology, 1970Summary Low levels of irreversibly sickled cells occur in patients with sickle‐cell anaemia and splenomegaly. The Hb F level appears to influence both the level of ISCs and the persistence of splenomegaly. It is suggested that low levels of ISCs allow splenomegaly to persist and hence are the cause and not primarily the result of persistent ...
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Southern Medical Journal, 1977
Hepatic dysfunction is a common finding in patients with sickle cell disease but viral hepatitis appears to be an unusual complication in the adult SS patient. Only five cases of viral hepatitis were recorded in 378 admissions for SS crisis. In contrast, hepatic crisis occurred as a distinct event in 9% of 88 patients with sickle cell anemia.
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Hepatic dysfunction is a common finding in patients with sickle cell disease but viral hepatitis appears to be an unusual complication in the adult SS patient. Only five cases of viral hepatitis were recorded in 378 admissions for SS crisis. In contrast, hepatic crisis occurred as a distinct event in 9% of 88 patients with sickle cell anemia.
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Nursing Standard, 2016
Essential facts Sickle cell disease is a group of disorders of red blood cells that is believed to affect up to 15,000 people in the UK. The lifelong condition can have a significant impact on morbidity and mortality.
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Essential facts Sickle cell disease is a group of disorders of red blood cells that is believed to affect up to 15,000 people in the UK. The lifelong condition can have a significant impact on morbidity and mortality.
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