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Sickle cell disease

Nursing Standard, 2016
Essential facts Sickle cell disease is a group of disorders of red blood cells that is believed to affect up to 15,000 people in the UK. The lifelong condition can have a significant impact on morbidity and mortality.
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Hemophagocytosis of Sickle Cells

New England Journal of Medicine, 2020
Hemophagocytosis of Sickle Cells A 60-year-old man with sickle cell disease presented with fatigue and shortness of breath.
Felix, Mensah, Monica, Pilichowska
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Irreversibly Sickled Cells and Splenomegaly in Sickle‐Cell Anaemia

British Journal of Haematology, 1970
Summary Low levels of irreversibly sickled cells occur in patients with sickle‐cell anaemia and splenomegaly. The Hb F level appears to influence both the level of ISCs and the persistence of splenomegaly. It is suggested that low levels of ISCs allow splenomegaly to persist and hence are the cause and not primarily the result of persistent ...
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Sickle cell kidney

Journal of Nephrology, 2008
Abstract Acute kidney injury is a rather unusual complication of sickle cell disease. We report a case of acute intrarenal sickling, causing dialysis-dependent acute renal failure, that was diagnosed by nuclear medicine renal imaging.
Andrew, Davenport, John, Buscombe
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Sickle Cell Biomechanics

Annual Review of Biomedical Engineering, 2010
As the predominant cell type in blood, red blood cells (RBCs) and their biomechanical properties largely determine the rheological and hemodynamic behavior of blood in normal and disease states. In sickle cell disease (SCD), mechanically fragile, poorly deformable RBCs contribute to impaired blood flow and other pathophysiological aspects of the ...
Gilda A, Barabino   +2 more
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Sickle Cell Anemia

American Journal of Diseases of Children, 1923
J. B. Herrick, 1 in 1910, reported a peculiar dyscrasia characterized by severe anemia, with the occurrence in the blood of elongated and sickle-shaped erythrocytes. Three instances of this condition have since been described, one by R. E. Washburn; 2 one by Cook and Myer, 3 and one by V. R. Mason. 4 Emmel 5 further studied the blood of Cook and Myer's
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The Reversibly Sickled Cell

Journal of Pediatric Hematology/Oncology, 1993
We have developed and applied simple techniques for the detection of irreversibly and reversibly sickled cells (ISCs and RSCs) in blood samples. Both ISCs and RSCs are found in the venous and arterial circulation, and sickling and unsickling occurs continuously in the tissues and arterial blood, respectively.Using these techniques, we have studied the ...
A, Zipursky, D M, Chachula, E J, Brown
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Sickle Cell Trait

JAMA: The Journal of the American Medical Association, 1974
THE assertion of black pride and aspiration has produced painful as well as happy readjustments: bloody civil strife together with burgeoning civil rights; abject mea culpa from some, abuse of the mea culpists by others; imposition of quotas welcomed today, to become cursed tomorrow.
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Sickle Cell Anemia

Annals of Internal Medicine, 1978
Excerpt To the editor: The "natural history" of sickle cell anemia in Saudi Arabs (Ann Intern Med88:1-6, 1978) is certainly different from the disease as we see it in the United States but not as d...
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Sickle-Cell Anemia

Issues in Comprehensive Pediatric Nursing, 1980
Sickle-cell anemia is a genetic disorder characterized by abnormal hemoglobin. One out of every 500 black children in the United States is affected by this disease. Eight to ten percent of the black population has the sickle-cell trait. While other hemoglobinopathies have been identified that also produce erythrocyte sickling and destruction, the ...
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