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Pediatric Clinics of North America, 2002
Sickle cell disease is a serious and life threatening disease that affects approximately 1 in 600 African-Americans. Since its first description in 1910 by Herrick, our understanding and treatment of this disease has grown tremendously. Most pediatricians will encounter one or more children with sickle cell disease and should have a thorough ...
Jason, Fixler, Lori, Styles
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Sickle cell disease is a serious and life threatening disease that affects approximately 1 in 600 African-Americans. Since its first description in 1910 by Herrick, our understanding and treatment of this disease has grown tremendously. Most pediatricians will encounter one or more children with sickle cell disease and should have a thorough ...
Jason, Fixler, Lori, Styles
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Archives of Pediatrics & Adolescent Medicine, 1979
Sir.—A recentJournalreport by Buchanan and Glader entitled, "Leukocyte Counts in Children With Sickle Cell Disease" (132:396-398, 1978), concluded in part that "an absolute band count greater than 1,000/μL suggests bacterial infection in children with sickle cell anemia." They found such a level in 14 of 16 episodes of bacterial infection but in only ...
C, Pegelow, D, Powars, G D, Overturf
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Sir.—A recentJournalreport by Buchanan and Glader entitled, "Leukocyte Counts in Children With Sickle Cell Disease" (132:396-398, 1978), concluded in part that "an absolute band count greater than 1,000/μL suggests bacterial infection in children with sickle cell anemia." They found such a level in 14 of 16 episodes of bacterial infection but in only ...
C, Pegelow, D, Powars, G D, Overturf
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THE SICKLE CELL DISEASES IN PREGNANCY
Obstetrical & Gynecological Survey, 1959Abstract 1. 1. Prenatal patients are screened for the sickle cell diseases by sickling preparations, followed by hemoglobin electrophoresis and alkali denaturation if sickling is positive. 2. 2. Six patients with sickle cell disease and three with sickle cell-C disease are reported. 3. 3.
J, ABRAMS, I R, SCHWARTZ
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Pediatric Clinics of North America, 1996
The identification of genetic mutation that causes sickle cell disease 35 years ago has not yet led to a widely applicable, specific therapy that corrects the underlying abnormality of hemoglobin. Nevertheless, recent progress in understanding the pathophysiology and natural history of sickling disorders has led directly to important prophylactic and ...
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The identification of genetic mutation that causes sickle cell disease 35 years ago has not yet led to a widely applicable, specific therapy that corrects the underlying abnormality of hemoglobin. Nevertheless, recent progress in understanding the pathophysiology and natural history of sickling disorders has led directly to important prophylactic and ...
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Hematology/Oncology Clinics of North America, 2005
The sickling disorders are a group of inherited diseases of the hemoglobin molecule characterized by chronic hemolytic anemia, increased susceptibility to infection, intermittent acute ‘crises,’ and progressive organ dysfunction as a result of vasoocclusion by the sickle erythrocytes.
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The sickling disorders are a group of inherited diseases of the hemoglobin molecule characterized by chronic hemolytic anemia, increased susceptibility to infection, intermittent acute ‘crises,’ and progressive organ dysfunction as a result of vasoocclusion by the sickle erythrocytes.
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2015
People with sickle cell disease, a chronic hemolytic anemia, present with a wide variety of neurological syndromes, including ischemic and hemorrhagic stroke, anterior and posterior territory transient ischemic attacks (TIAs), "soft neurological signs," seizures, headache, coma, visual loss, and altered mental status.
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People with sickle cell disease, a chronic hemolytic anemia, present with a wide variety of neurological syndromes, including ischemic and hemorrhagic stroke, anterior and posterior territory transient ischemic attacks (TIAs), "soft neurological signs," seizures, headache, coma, visual loss, and altered mental status.
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Enuresis in Sickle Cell Disease
The Journal of Urology, 1995The prevalence of enuresis and management options for this condition were studied in our population of sickle cell patients. A total of 91 active patients (6 to 21 years old) followed at our regional sickle cell center was surveyed for the symptoms of primary nocturnal enuresis. Of the 91 patients 27 (29.6%) had primary nocturnal enuresis.
T E, Figueroa +3 more
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The spine in sickle cell disease
International Orthopaedics, 1994Bone changes in sickle cell disease occur due to marrow hyperplasia, tissue ischaemia and infarction due to vaso-occlusion. Between 1982 and 1991 thirty four patients were treated in the Orthopaedic and Neurosurgery Departments of the Kind Fahd University Hospital, Al-Khobar, with spinal complications due to sickle cell disease. There were 21 males and
M, Sadat-Ali +3 more
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Sickle Cell Disease and the Kidney
Seminars in Nephrology, 2003Sickle cell disease (SCD) affects the kidney by acute mechanisms, as a form of the sickle crisis, and insidiously with renal medullary/papillary necrosis, with resulting tubular defects. Glomerular hyperperfusion and hypertrophy results in a chronic sickle cell nephropathy that results in a significant morbidity in the progression to end-stage kidney ...
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Management of sickle cell disease
BMJ, 2008Hypoxia, hemolysis and infection are more or less associated in patients affected with sickle cell disease. Treatment is based on a programme including regular lifestyle, hydration, folic acid supply, prevention of pneumococcal infections and cerebrovascular events in children, regular follow-up in specialised centres allowing precocious screening and ...
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