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Pediatric Clinics of North America, 1996
The identification of genetic mutation that causes sickle cell disease 35 years ago has not yet led to a widely applicable, specific therapy that corrects the underlying abnormality of hemoglobin. Nevertheless, recent progress in understanding the pathophysiology and natural history of sickling disorders has led directly to important prophylactic and ...
P. Lane
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The identification of genetic mutation that causes sickle cell disease 35 years ago has not yet led to a widely applicable, specific therapy that corrects the underlying abnormality of hemoglobin. Nevertheless, recent progress in understanding the pathophysiology and natural history of sickling disorders has led directly to important prophylactic and ...
P. Lane
semanticscholar +3 more sources
Sickle Cell Disease: A Review.
Journal of the American Medical Association (JAMA), 2022Importance Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized by formation of long chains of hemoglobin when deoxygenated within capillary beds, resulting in sickle-shaped red blood cells, progressive multiorgan damage, and ...
P. Kavanagh, Titilope A Fasipe, T. Wun
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Annals of Internal Medicine, 2021
Sickle cell disease is an umbrella term for a group of hemoglobinopathies characterized by the presence of 2 β-globin gene mutations or deletions, at least 1 of which is the point mutation that leads to the production of hemoglobin S. Sickle cell disease is associated with hemolytic anemia, significant chronic end-organ damage, and early death. In high-
Lydia H. Pecker, Sophie Lanzkron
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Sickle cell disease is an umbrella term for a group of hemoglobinopathies characterized by the presence of 2 β-globin gene mutations or deletions, at least 1 of which is the point mutation that leads to the production of hemoglobin S. Sickle cell disease is associated with hemolytic anemia, significant chronic end-organ damage, and early death. In high-
Lydia H. Pecker, Sophie Lanzkron
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Journal of the American Medical Association (JAMA), 2014
IMPORTANCE Sickle cell disease (SCD) is a life-threatening genetic disorder affecting nearly 100,000 individuals in the United States and is associated with many acute and chronic complications requiring immediate medical attention. Two disease-modifying
B. Yawn +18 more
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IMPORTANCE Sickle cell disease (SCD) is a life-threatening genetic disorder affecting nearly 100,000 individuals in the United States and is associated with many acute and chronic complications requiring immediate medical attention. Two disease-modifying
B. Yawn +18 more
semanticscholar +1 more source
Pediatric Clinics of North America, 2002
Sickle cell disease is a serious and life threatening disease that affects approximately 1 in 600 African-Americans. Since its first description in 1910 by Herrick, our understanding and treatment of this disease has grown tremendously. Most pediatricians will encounter one or more children with sickle cell disease and should have a thorough ...
Jason Fixler, Lori Styles
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Sickle cell disease is a serious and life threatening disease that affects approximately 1 in 600 African-Americans. Since its first description in 1910 by Herrick, our understanding and treatment of this disease has grown tremendously. Most pediatricians will encounter one or more children with sickle cell disease and should have a thorough ...
Jason Fixler, Lori Styles
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Nursing Standard, 2016
Essential facts Sickle cell disease is a group of disorders of red blood cells that is believed to affect up to 15,000 people in the UK. The lifelong condition can have a significant impact on morbidity and mortality.
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Essential facts Sickle cell disease is a group of disorders of red blood cells that is believed to affect up to 15,000 people in the UK. The lifelong condition can have a significant impact on morbidity and mortality.
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Archives of Pediatrics & Adolescent Medicine, 1979
Sir.—A recentJournalreport by Buchanan and Glader entitled, "Leukocyte Counts in Children With Sickle Cell Disease" (132:396-398, 1978), concluded in part that "an absolute band count greater than 1,000/μL suggests bacterial infection in children with sickle cell anemia." They found such a level in 14 of 16 episodes of bacterial infection but in only ...
Darleen R. Powars +2 more
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Sir.—A recentJournalreport by Buchanan and Glader entitled, "Leukocyte Counts in Children With Sickle Cell Disease" (132:396-398, 1978), concluded in part that "an absolute band count greater than 1,000/μL suggests bacterial infection in children with sickle cell anemia." They found such a level in 14 of 16 episodes of bacterial infection but in only ...
Darleen R. Powars +2 more
openaire +3 more sources
Clinical evidence, 2005
Sickle cell disease causes chronic haemolytic anaemia, dactylitis, and painful acute crises, and increases the risk of stroke, organ damage, bacterial infections, and complications of blood transfusion. In sub-Saharan Africa, up to a third of adults are carriers of the defective sickle cell gene, and 1-2% of babies are born with the disease.We ...
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Sickle cell disease causes chronic haemolytic anaemia, dactylitis, and painful acute crises, and increases the risk of stroke, organ damage, bacterial infections, and complications of blood transfusion. In sub-Saharan Africa, up to a third of adults are carriers of the defective sickle cell gene, and 1-2% of babies are born with the disease.We ...
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Annals of Internal Medicine, 2009
This issue provides a clinical overview of sickle cell disease focusing on prevention, diagnosis, treatment, practice improvement, and patient information. Readers can complete the accompanying CME quiz for 1.5 credits. Only ACP members and individual subscribers can access the electronic features of In the Clinic.
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This issue provides a clinical overview of sickle cell disease focusing on prevention, diagnosis, treatment, practice improvement, and patient information. Readers can complete the accompanying CME quiz for 1.5 credits. Only ACP members and individual subscribers can access the electronic features of In the Clinic.
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A Review of Automated Methods for the Detection of Sickle Cell Disease
IEEE Reviews in Biomedical Engineering, 2020Detection of sickle cell disease is a crucial job in medical image analysis. It emphasizes elaborate analysis of proper disease diagnosis after accurate detection followed by a classification of irregularities, which plays a vital role in the sickle cell
P. Das +3 more
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