Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior [PDF]
Journal of Neuroinflammation, 2011 Background Interleukin (IL)-6 is produced in the brain during peripheral infection and plays an important but poorly understood role in sickness behavior.
Johnson Rodney W +2 more
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No evidence of sickness behavior in immune‐challenged field crickets [PDF]
Ecology and Evolution, 2020 Sickness behavior is a taxonomically widespread coordinated set of behavioral changes that increases shelter‐seeking while reducing levels of general activity, as well as food (anorexia) and water (adipsia) consumption, when fighting infection by ...
Clint D. Kelly, Jules Mc Cabe Leroux
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Sickness Behavior in Honey Bees. [PDF]
Front Physiol, 2016 During an infection, animals suffer several changes in their normal physiology and behavior which may include lethargy, appetite loss, and reduction in grooming and general movements. This set of alterations is known as sickness behavior and although it has been extensively believed to be orchestrated primarily by the immune system, a relevant role for
Kazlauskas N +3 more
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Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia. [PDF]
PLoS ONE, 2018 Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect.
Ching-Hua Yeh +6 more
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Sickness behavior and seasonal affective disorder: An immunological perspective of depression
Indian Journal of Psychological Medicine, 2018 We describe a case of 45-year-old female suffering from chronic hepatitis B and bronchial asthma who presented with symptoms of seasonal affective disorder and sickness behavior.
Pooja Patnaik Kuppili +2 more
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The Legacy of Sickness Behaviors [PDF]
Frontiers in Psychiatry, 2020 Systemic infections of all types lead to a syndrome known as sickness behaviors. Changes in the behavior of febrile humans and animals formed the original basis for this concept. Body temperature is behaviorally regulated in both endotherms and ectotherms.
Keith W. Kelley +4 more
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Zinc prevents sickness behavior induced by lipopolysaccharides after a stress challenge in rats. [PDF]
PLoS ONE, 2015 Sickness behavior is considered part of the specific beneficial adaptive behavioral and neuroimmune changes that occur in individuals in response to infectious/inflammatory processes.
Thiago B Kirsten +4 more
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How Does the Social Grouping of Animals in Nature Protect Against Sickness? A Perspective
Frontiers in Behavioral Neuroscience, 2021 Sickness behavior is broadly represented in vertebrates, usually in association with the fever response in response to acute infections. The reactions to sickness behavior in a group member or potential group member in humans is quite variable, depending
Lynette A. Hart, Benjamin L. Hart
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Prevention of LPS-induced microglia activation, cytokine production and sickness behavior with TLR4 receptor interfering peptides. [PDF]
PLoS ONE, 2013 The innate immune receptor Toll-like 4 (TLR4) is the receptor activated by lipopolysaccharide (LPS), and TLR4-LPS interaction is well known to induce an innate immune response, triggering sickness behavior.
Dustin J Hines +4 more
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European Psychiatry, 2022 Introduction A cross-sectional relationship between low-grade inflammation –characterized by increased blood levels of C-reactive protein (CRP) and pro-inflammatory cytokines– and both MDD and anxiety has been reported, but the potential longitudinal ...
W. Van Eeden
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