Results 191 to 200 of about 13,350,888 (315)

Large-scale analysis demonstrates the influence of CYP2C19 genotype on specific SSRI side effects. [PDF]

Pharmacogenomics J
Eijsbouts C, Jiang Y, Ashenhurst JR, Granka JM, 23andMe Research Team, Pitts S, Auton A, Abul-Husn NS, Chubb A, Wu RR.   +9 more
europepmc   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Circadian Genotypes in PER3 and Time of Prostate Cancer Radiotherapy Interact to Affect Risk of Late Side Effects. [PDF]

Clin Cancer Res
Webb AJ, Harper E, Rattay T, Aguado-Barrera ME, Avuzzi B, Bultijnck R, Choudhury A, De Ruysscher DK, Fuentes-Ríos O, Gutiérrez-Enríquez S, Kerns SL, Lobato-Busto R, McWilliam A, Noris Chiorda B, Rancati T, Rosenstein BS, Seibold P, Sperk E, Vega A, Veldeman L, Ward TH, West CM, Symonds P, Talbot CJ, REQUITE Consortium, REQUITE Consortium.   +25 more
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

A Blockchain Platform for Vaccine Beneficiary Registration, Side Effects, Cold Supply Chain, and Personnel Training and Employment Management. [PDF]

Sensors (Basel)
Sadawi AA, Ndiaye MM, Al Khaffaf I, Abdulkarim O.   +3 more
europepmc   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Chemical components of tattoo inks and their potential role in carcinogenesis and their side effects. [PDF]

Arch Toxicol
Czaczkowska L, Jabłońska E, Bury J, Szurant N, Ratajczak-Wrona W.   +4 more
europepmc   +1 more source

Side effects of prazocin [PDF]

BMJ, 1976
openaire   +2 more sources

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Comment on: Immune checkpoint inhibitor therapy for treatment of periocular Merkel cell carcinoma - Exploring ocular side effects. [PDF]

Indian J Ophthalmol
Sanjay S.
europepmc   +1 more source