Results 221 to 230 of about 21,712,270 (345)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Side Effects of First-Line Anti-tubercular Therapy (ATT): Does an Alternative Regimen Exist? [PDF]

Cureus
Goswami G, Nirala P, Tandon R, Kalra P, Tariq M, Singh L.   +5 more
europepmc   +1 more source

Structure-based discovery of opioid analgesics with reduced side effects

Nature, 2016
A. Manglik, Henry Lin, Dipendra K. Aryal, J. McCorvy, D. Dengler, G. Corder, A. Levit, Ralf C. Kling, Viachaslau Bernat, H. Hübner, Xi-Ping Huang, M. Sassano, P. Giguère, S. Löber, D. Duan, G. Scherrer, B. Kobilka, P. Gmeiner, B. Roth, B. Shoichet   +19 more
semanticscholar   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Quality and reliability of semaglutide content on different Chinese short video platforms: a study focusing on side effects. [PDF]

Front Public Health
Song J, He X, Cui Z, Sun Y, Liu Y, Yu H, Li A, Jin M.   +7 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Side effects of metal-based dental implantology treatment - A review. [PDF]

Bioinformation
Gupta DK, Sethi S, Jha A, Thakur A, Gupta K.   +4 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Targeting Dermatologic Side Effects of Immunotherapy Using Novel Skin Care Products. [PDF]

J Cancer
Claes M, Lodewijckx J, Robijns J, Tuts L, Lenaerts M, Vandaele E, Wessels T, Requilé A, Luyten D, Verheezen Y, Joosens E, Mebis J.   +11 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source