Results 31 to 40 of about 4,809,367 (307)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Centrifugal model tests on vertical bearing characteristics of undercompacted slope piles
Yantu gongcheng xuebaoThe existing theories and experience of pile foundation are based on the flat slopes, and the stress characteristics of undercompacted slope piles are quite different from those of flat slope piles.
REN Jiali , CHENG Yonghui , LI bo, HU Shenggang , ZHANG Huawei
doaj +1 more source
Advanced Composites Letters, 2019 It is difficult to monitor lightning damage to carbon fibre-reinforced polymers (CFRPs) online. This work experimentally investigates the changes associated with the electrical resistance of CFRPs subjected to lightning strikes.
Jian Chen, Zhengcai Fu, Yang Zhao
doaj +1 more source
Load-Bearing Characteristics of Large-Diameter Rock-Socketed Piles Based on Ultimate Load Tests
Advances in Materials Science and Engineering, 2020 As part of a large converter project in Shandong Province, vertical static load tests and internal force tests were conducted on three large-diameter rock-socketed piles, their load transfer mechanism was clarified, and the ultimate side resistance and ...
Xueying Liu +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Experimental Study on Penetration Mechanical Mechanism of Jacked Pile in Clayey Soil
工程科学与技术, 2020 For open-ended jacked pipe pile, the pile body is subjected to complex forces during pile jacking, especially the soil plug resistance caused by soil plug effect inside the pile body, which has a significant influence on the pile side resistance ...
Yonghong WANG +3 more
doaj
Soil arching effect analysis and structure optimization of a robot foot sinking in soft soil
Advances in Mechanical Engineering, 2017 In this study, to analyze the influence of the cross-sectional shape of a rigid foot on its sinking performance in soft soil, a numerical model of the subsidence of a single leg was built using the arbitrary Lagrangian–Eulerian method in ABAQUS to ...
Gang He +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Actuators, 2023 In the realm of high-speed precision broadcasting, the existing seeder opener proves inadequate for the speed of the seeding operation. We focus on the duckbill opener and employ the quadratic regression orthogonal rotation combination test design method
Weipeng Zhang +9 more
doaj +1 more source
A Side-Channel Attack Resistive ECDSA
Journal of Physics: Conference Series, 2020 Abstract Elliptic curve plays an important role in securing critical software applications as it is one of the most powerful and widely utilized encryption algorithms. It is used in many applications such as digital signature schemes. Elliptic curve algorithms are hard to break, however, attackers find another indirect and more efficient
A. Samir Abo-Taleb +3 more
openaire +1 more source